A set of clinical and laboratory markers differentiates hyper-IgE syndrome from severe atopic dermatitis

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dc.authoridFunda Erol Çipe / 0000-0002-9718-7507
dc.authorscopusidFunda Erol Çipe / 25824763200
dc.authorwosidFunda Erol Çipe / GDE-8701-2022
dc.contributor.authorKasap, Nurhan
dc.contributor.authorÇelik, Velat
dc.contributor.authorIşık, Sakine
dc.contributor.authorCennetoğlu, Pakize
dc.contributor.authorKıykım, Ayça
dc.contributor.authorBilgiç Eltan, Sevgi
dc.contributor.authorNain, Ercan
dc.contributor.authorOğulur, İsmail
dc.contributor.authorBaşer, Dilek
dc.contributor.authorAkkelle, Emre
dc.contributor.authorÇeliksoy, Mehmet Halil
dc.contributor.authorKocamış, Burcu
dc.contributor.authorErol Çipe, Funda
dc.contributor.authorYücelten, Ayşe Deniz
dc.contributor.authorKarakoç Aydıner, Elif
dc.contributor.authorÖzen, Ahmet
dc.contributor.authorBarış, Safa
dc.date.accessioned2020-12-17T10:04:59Z
dc.date.available2020-12-17T10:04:59Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractHyper-IgE syndrome (HIES) patients may share many features observed in severe atopic dermatitis (SAD), making a diagnostic dilemma for physicians. Determining clinical and laboratory markers that distinguish both disorders could provide early diagnosis and treatment. We analyzed patients (DOCK8 deficiency:14, STAT3-HIES:10, SAD:10) with early-onset SAD. Recurrent upper respiratory tract infection and pneumonia were significantly frequent in HIES than SAD patients. Characteristic facial appearance, retained primary teeth, skin abscess, newborn rash, and pneumatocele were more predictable for STAT3-HIES, while mucocutaneous candidiasis and Herpes infection were common in DOCK8 deficiency, which were unusual in SAD group. DOCK8-deficient patients had lower CD3+ and CD4+T cells with a senescent phenotype that unique for this form of HIES. Both DOCK8 deficiency and STAT3-HIES patients exhibited reduced switched memory B cells compared to the SAD patients. These clinical and laboratory markers are helpful to differentiate HIES from SAD patients.en_US
dc.identifier.citationKasap, N., Celik, V., Isik, S., Cennetoglu, P., Kiykim, A., Eltan, S. B., Nain, E., Ogulur, I., Baser, D., Akkelle, E., Celiksoy, M. H., Kocamis, B., Cipe, F. E., Yucelten, A. D., Aydiner, E. K., Ozen, A., & Baris, S. (2020). A set of clinical and laboratory markers differentiates hyper-IgE syndrome from severe atopic dermatitis. Clinical immunology (Orlando, Fla.), 108645. Advance online publication. https://doi.org/10.1016/j.clim.2020.108645en_US
dc.identifier.doi10.1016/j.clim.2020.108645en_US
dc.identifier.issn1521-6616en_US
dc.identifier.pmid33301882en_US
dc.identifier.scopus2-s2.0-85097777826en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.clim.2020.108645
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1283
dc.identifier.wosWOS:000613283300013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErol Çipe, Funda
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofClinical immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDOCK8 Deficiencyen_US
dc.subjectHyper-IgE Syndromeen_US
dc.subjectSTAT3 Deficiencyen_US
dc.subjectSevere Atopic Dermatitisen_US
dc.titleA set of clinical and laboratory markers differentiates hyper-IgE syndrome from severe atopic dermatitisen_US
dc.typeArticleen_US

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