Hepatitis-associated aplastic anemia: etiology, clinical characteristics and outcome

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dc.authoridGül Nihal Özdemir / 0000-0002-3204-4353en_US
dc.authorscopusidGül Nihal Özdemir / 34067792800
dc.authorwosidGül Nihal Özdemir / AAO-9962-2020
dc.contributor.authorTüfekçi, Özlem
dc.contributor.authorÖzdemir, Hamiyet Hekimci
dc.contributor.authorMalbora, Barış
dc.contributor.authorÖzbek, Namık Yaşar
dc.contributor.authorYaralı, Neşe
dc.contributor.authorErdem, Arzu Yazal
dc.contributor.authorEvim, Melike Sezgin
dc.contributor.authorÖzdemir, Gül Nihal
dc.date.accessioned2021-08-31T12:29:41Z
dc.date.available2021-08-31T12:29:41Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractHepatitis-associated aplastic anemia (HAA) is a form of acquired aplastic anemia (AA) in which bone marrow failure develops after an acute attack of hepatitis. Bone marrow failure leading to AA is generally severe in cases of HAA and fatal if left untreated. This retrospective multicenter study investigated clinical and laboratory characteristics, possible causes, treatment, and outcome of HAA in children. Twenty patients from 8 centers were included in the study. Aspartate aminotransferase and alanine aminotransferase were <3 to 5×upper limit of normal (ULN) in 2 patients, <5 to 10×ULN in 2 patients, and >10×ULN in 16 patients. Acute liver failure developed in 5 (29%) patients. Pancytopenia was simultaneously present in 6 of 20 (30%) patients. Eleven of the 20 patients (55%) were alive, in remission and transfusion free. Those who were alive either had undergone hematopoietic stem cell transplantation and/or immunosuppressive treatment, except 1 patient who had received no treatment. Patients with the diagnosis of acute hepatitis should be evaluated and followed up carefully for presence of cytopenia, so that definitive treatment of AA can be initiated in a timely and appropriate manner when needed. Copyright r 2021 Wolters Kluwer Health, Inc.en_US
dc.identifier.citationTüfekçi, Ö., Özdemir, H. H., Malbora, B., Özbek, N. Y., Yarali, N., Erdem, A., ... & Karapinar, D. Y. (2021). Hepatitis-Associated Aplastic Anemia: Etiology, Clinical Characteristics and Outcome. Journal of Pediatric Hematology/Oncology.en_US
dc.identifier.doi10.1097/MPH.0000000000002268en_US
dc.identifier.issn1077-4114en_US
dc.identifier.pmid34669357en_US
dc.identifier.scopus2-s2.0-85112841593en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1097/MPH.0000000000002268
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2013
dc.identifier.wosWOS:000739432300042en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzdemir, Gül Nihal
dc.language.isoenen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.ispartofJournal of Pediatric Hematology/Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAplastic Anemiaen_US
dc.subjectHepatitisen_US
dc.subjectHepatitis-Associated Aplastic Anemiaen_US
dc.titleHepatitis-associated aplastic anemia: etiology, clinical characteristics and outcomeen_US
dc.typeArticleen_US

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