Topical metformin accelerates wound healing by promoting collagen synthesis and inhibiting apoptosis in a diabetic wound model

Basit Öğe Kaydı
dc.authoridSOYDAS, Tugba/0000-0002-0684-1906
dc.authoridTombultürk, Fatma Kübra/0000-0002-4358-2309
dc.authorwosidSOYDAS, Tugba/ACK-6027-2022
dc.authorwosidTombultürk, Fatma Kübra/L-3969-2018
dc.contributor.authorTombulturk, Fatma Kubra
dc.contributor.authorSoydas, Tugba
dc.contributor.authorKanigur-Sultuybek, Gonul
dc.date.accessioned2024-05-19T14:39:06Z
dc.date.available2024-05-19T14:39:06Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThe wound healing process, which is a pathophysiological process that includes various phases, is interrupted in diabetes due to hyperglycemia, and since deterioration occurs in these phases, a normal healing process is not observed. The aim of the current study is to investigate the proliferative and antiapoptotic effects of metformin on wound healing after topical application on diabetic and non-diabetic wounds. For this purpose, we applied metformin topically on the full-thickness excisional wound model we created in diabetic and nondiabetic groups. We investigated the effects of metformin on the apoptotic index by the Terminal deoxynucleotidyl transferase mediated dUTP Nick-End Labeling method and on collagen-I, collagen-III, p53, and c-jun expression levels by quantitative reverse transcription polymerase chain reaction technique in wound biopsy tissues. Our results showed that c-jun and p53 mRNA levels and apoptotic index increased with the effect of diabetes, while collagen synthesis was disrupted. As a result of the study, we showed that metformin increases cellular proliferation and has anti-apoptotic effects by increasing collagen-I/III expression and decreasing p53/c-jun level, especially in diabetic wounds and also in normal wounds. In conclusion, the topical effect of metformin on diabetic wounds reversed the adverse effects caused by diabetes, increasing the wound healing rate and improving the wound repair process.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [120S628]en_US
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkey (TUBITAK), Grant/Award Number: 120S628en_US
dc.identifier.doi10.1111/iwj.14345
dc.identifier.issn1742-4801
dc.identifier.issn1742-481X
dc.identifier.issue1en_US
dc.identifier.pmid37565543en_US
dc.identifier.scopus2-s2.0-85167711914en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1111/iwj.14345
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4702
dc.identifier.volume21en_US
dc.identifier.wosWOS:001046434900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Wound Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectApoptosisen_US
dc.subjectCollagenen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectMetforminen_US
dc.subjectWound Healingen_US
dc.titleTopical metformin accelerates wound healing by promoting collagen synthesis and inhibiting apoptosis in a diabetic wound modelen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu