The effect of mesenchymal stromal cells ın the microenvironment on cancer development

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dc.authoridErdal Karaöz / 0000-0002-9992-833Xen_US
dc.authorscopusidErdal Karaöz / 7003448087
dc.authorwosidErdal Karaöz / IXE-6677-2023en_US
dc.contributor.authorÖzlem Sağlam-Uça
dc.contributor.authorİrfan Değirmenci
dc.contributor.authorHalbutoğulları, Zehra Seda
dc.contributor.authorPosteki, Gökhan
dc.contributor.authorSubaşı-Demirci, Cansu
dc.contributor.authorErman, Gülay
dc.contributor.authorKaraöz, Erdal
dc.contributor.authorUtkan, N. Zafer
dc.date.accessioned2022-06-15T13:48:46Z
dc.date.available2022-06-15T13:48:46Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractInfammatory signals secreted from the tumor microenvironment are thought to promote tumor growth and survival. It has been reported that stromal cells in the tumor microenvironment have similar characteristics to tumor-associated cells. In addition miRNAs play critical roles in various diseases, including cancer. In this study, we aimed to investigate the efects of co-culture of cancer cells and stromal cells isolated from normal and malignant breast tissue on each other and the possible efects of miRNAs on these interactions. The characterized stromal cells were co-cultured with an MDA-MB-231 cancer cell line. The proliferation capacity of the experimental groups was evaluated using the WST-1 assay. The expression of breast cancer-specifc miRNAs and related genes were assessed by real-time PCR. ELISA assay was performed to determine the concentration of some cytokines and chemokines. We found that the microenvironment plays an important role in the development of cancer, confrming the changes in the expression of oncogenic and tumor suppressor miRNA and their target genes after co-culture with malignant stromal cells. As a result of the studies, specifc gene expressions of related signaling pathways were detected in correlation with miRNA changes and the efects of tumor microenvironment on tumorigenesis were revealed in detail. miRNAs have been shown to play an important role in cancer development in recent studies. The idea that these small molecules can be used in diagnosis and treatment is becoming stronger day by day. We believe that new treatment approaches involving the tumor microenvironment and using miRNAs as markers are promisingen_US
dc.identifier.citationSağlam-Uçar Ö, Değirmenci İ, Halbutoğullari ZS, Pösteki G, Subaşi-Demirci C, Erman G, Karaöz E, Utkan NZ. The effect of mesenchymal stromal cells ın the microenvironment on cancer development. Med Oncol. 2022 Jun 8;39(8):114. doi: 10.1007/s12032-022-01703-1. PMID: 35674854.en_US
dc.identifier.doi10.1007/s12032-022-01703-1en_US
dc.identifier.issue114en_US
dc.identifier.pmid35674854en_US
dc.identifier.scopus2-s2.0-85131772615en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttp://doi.org/10.1007/s12032-022-01703-1
dc.identifier.uri1357-0560
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2904
dc.identifier.volume39en_US
dc.identifier.wosWOS:000808339400002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaraöz, Erdal
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMedical Oncologyen_US
dc.relation.publicationcategoryMakale - Ulusal - Editör Denetimli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectMesenchymal Stromal Cellen_US
dc.subjectMicroenvironmenten_US
dc.subjectMiRNAen_US
dc.titleThe effect of mesenchymal stromal cells ın the microenvironment on cancer developmenten_US
dc.typeArticleen_US

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