A case report of giant malignant schwannoma of the sciatic nerve associated with neurofibromatosis-1: A CARE-compliant article

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dc.authoridgokkus, kemal/0000-0002-4916-3471
dc.authorwosidgokkus, kemal/A-4410-2016
dc.contributor.authorGokkus, Kemal
dc.contributor.authorSaylik, Murat
dc.contributor.authorBirtay, Tayfun
dc.contributor.authorSahin, Mehmet Sukru
dc.date.accessioned2024-05-19T14:43:09Z
dc.date.available2024-05-19T14:43:09Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractRationale:Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous syndrome that causes multiple central and peripheral nerve sheath tumors. People with NF1 have a 10% chance of developing malignant peripheral nerve sheath tumors (MPNSTs). Here we report a unique instance of a malignant schwannoma that has remained free of metastasis since its initial removal a decade ago. The malign schwannoma has been infrequently documented in the literature, and remarkably, no instances of such an extensive postoperative time without metastases have ever been described.Patient concerns:A 46-year-old male patient with NF had multiple neurofibromas in different parts of his body, underwent surgery about 10 years ago (2013), and was diagnosed histopathologically as MPNST.Diagnoses:He was admitted to our institution with a recurrent mass in the posterior third of the proximal thigh and severe pain radiating to the left lower extremity, which presented as sciatic pain (2021). A magnetic resonance imaging and fluorodeoxyglucose-positron emission tomography examination revealed that the tumor was likely malignant.Interventions:Surgical excision was performed.Outcome:A 10-year follow-up revealed no metastases or neurologic impairment.Lessons:When articles about benign schwannomas are placed in a separate category, little is written about NF-1-related malignant schwannomas of the sciatic nerve. MPNSTs are high-grade, aggressive sarcomas with a high risk of local recurrence (40%-65%) and metastasis to other body parts. Therefore, among the various benign peripheral nerve sheath tumors in NF-1 patients, the diagnosis of MPNST is crucial.Orthopedic surgeons should be aware that neurofibromas in NF-1 have a significant risk of developing MPNSTs. This study reports the successful treatment of a giant malignant sciatic nerve schwannoma with a long follow-up period without metastasis.Lessons:When articles about benign schwannomas are placed in a separate category, little is written about NF-1-related malignant schwannomas of the sciatic nerve. MPNSTs are high-grade, aggressive sarcomas with a high risk of local recurrence (40%-65%) and metastasis to other body parts. Therefore, among the various benign peripheral nerve sheath tumors in NF-1 patients, the diagnosis of MPNST is crucial.Orthopedic surgeons should be aware that neurofibromas in NF-1 have a significant risk of developing MPNSTs. This study reports the successful treatment of a giant malignant sciatic nerve schwannoma with a long follow-up period without metastasis.en_US
dc.identifier.doi10.1097/MD.0000000000036358
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue47en_US
dc.identifier.pmid38013269en_US
dc.identifier.scopus2-s2.0-85178046265en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org10.1097/MD.0000000000036358
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5327
dc.identifier.volume102en_US
dc.identifier.wosWOS:001116496400021en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofMedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectMalignant Peripheral Nerve Sheath Tumorsen_US
dc.subjectMalignant Schwannomaen_US
dc.subjectNeurofibromatosis-1en_US
dc.subjectSciatic Nerveen_US
dc.subjectSciaticaen_US
dc.titleA case report of giant malignant schwannoma of the sciatic nerve associated with neurofibromatosis-1: A CARE-compliant articleen_US
dc.typeArticleen_US

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