Pre-transplantation vitamin D deficiency increases acute graft-versus-host disease after hematopoietic stem cell transplantation in thalassemia major patients

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dc.authoridVedat Uygun / 0000-0003-3257-7798en_US
dc.authorscopusidVedat Uygun / 10043117000
dc.authorwosidVedat Uygun / AGH-4534-2022en_US
dc.contributor.authorDaloğlu, Hayriye
dc.contributor.authorUygun, Vedat
dc.contributor.authorÖztürkmen, Seda
dc.contributor.authorYalçın, Koray
dc.contributor.authorKarasu, Gülsü
dc.contributor.authorYeşilipek, Akif
dc.date.accessioned2023-01-26T12:30:53Z
dc.date.available2023-01-26T12:30:53Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Although there are many studies on the role of vitamin D deficiency (VDD) in hematopoetic stem cell transplantation (HSCT), outcomes have often reported conflicting results because of the heterogeneity of the patients in the studies. Methods: We investigated the association between VDD prior to HSCT and outcomes after HSCT in a relatively homogenous group of patients with thalassemia major (TM) who received identical treatment for TM before transplantation, and the same conditioning regimen and GVHD prophylaxis during and after transplantation. All patients, including the patients with normal vitamin D3 levels received 400 to 800 IU per day of vitamin D for the first 6 months after HSCT. Results: Pre-HSCT VDD increased the frequency of aGVHD after transplantation, particularly in HSCTs performed with PBSC for the stem cell source. Pre-transplant low vitamin D3 levels had no association with transplant outcomes such as engraftment, viral infections, alloimmunization, chronic GvHD, total days of hospitalization, and success in terms of transfusion independence. Conclusions: Low vitamin D3 levels before HSCT carry a significant risk for aGVHD. All patients with TM should be screened for VDD before HSCT, and every effort should be made to supplement vitamin D before the transplant in VDD patientsen_US
dc.identifier.citationDaloğlu, H., Uygun, V., Öztürkmen, S., Yalçın, K., Karasu, G., & Yeşilipek, A. (2022). Pre-transplantation vitamin D deficiency increases acute graft-versus-host disease after hematopoietic stem cell transplantation in thalassemia major patients. Clinical transplantation, e14874. Advance online publication. https://doi.org/10.1111/ctr.14874en_US
dc.identifier.doi10.1111/ctr.14874en_US
dc.identifier.pmid36461145en_US
dc.identifier.scopus2-s2.0-85144055421en_US
dc.identifier.urihttp://dx.doi.org/10.1111/ctr.14874
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3841
dc.identifier.wosWOS:000898082000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUygun, Vedat
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofClinical transplantatioen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Graft Versus Host Diseaseen_US
dc.subjectChildrenen_US
dc.subjectHematopoetic Stem Cell Transplantationen_US
dc.subjectThalassemia Majoren_US
dc.subjectVitamin Den_US
dc.titlePre-transplantation vitamin D deficiency increases acute graft-versus-host disease after hematopoietic stem cell transplantation in thalassemia major patientsen_US
dc.typeArticleen_US

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