The healing effects of the topical mesenchymal stem cell application on colonic anastomosis subjected to ischemia reperfusion injury

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dc.authoridHuri Bulut / 0000-0003-2706-9625en_US
dc.authorscopusidHuri Bulut / 57185264300
dc.authorwosidHuri Bulut / AAM-1432-2020
dc.contributor.authorÖzden, Hüseyin
dc.contributor.authorKaraca, Gökhan
dc.contributor.authorBulut, Huri
dc.contributor.authorNiyaz, Mehmet
dc.contributor.authorGömeç, Muhammed
dc.contributor.authorDaphan, Çağatay E.
dc.date.accessioned2021-10-18T13:25:20Z
dc.date.available2021-10-18T13:25:20Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractIntestinal ischemia reperfusion injury (IRI) is a challenging problem and it adversely affects the healing of colonic anastomosis. Our experimental study aimed to investigate the role of mesenchymal stem cells (MSC) administration in the healing of colonic anastomosis. A total of 33 rats were grouped as Control, IRI and MSC treatment groups. Three rats were reserved for obtaining MSCs. Colonic resection and anastomosis procedure was performed in all groups. Anastomotic line was wrapped with MSCs impregnated spongostan after colonic anastomosis in the rats of the MSC treatment group. All rats were sacrificed and anastomotic line were sampled for examination on the post operative seventh day. Tissue hydroxyproline (HP) levels and anastomotic bursting pressures were statistically compared. Anastomotic bursting pressures were found to be significantly high in MSC treatment group rats. The lowest anastomotic bursting pressure was detected in IRI group rats. Hydroxyproline content of the anastomotic sites were also found to be significantly higher in the rats of the MSC treatment group when compared with the IRI group rats. Our study showed that the detrimental effects of IRI on the healing process of colonic anastomosis in an experimental model may be alleviated with the treatment of MSCs.en_US
dc.identifier.citationÖZDEN, H., KARACA, G., BULUT, H., NİYAZ, M., GÖMEÇ, M., & Çağatay, E. D. The Healing Effects of The Topical Mesenchymal Stem Cells Application on Colonic Anastomosis Subjected to Ischemia Reperfusion Injury.en_US
dc.identifier.doi10.9775/kvfd.2021.25935en_US
dc.identifier.endpage600en_US
dc.identifier.issn1300-6045en_US
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85116499298en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage595en_US
dc.identifier.trdizinid484454en_US
dc.identifier.urihttps://doi.org/10.9775/kvfd.2021.25935
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2155
dc.identifier.volume27en_US
dc.identifier.wosWOS:000704282200008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorBulut, Huri
dc.language.isoenen_US
dc.publisherKAFKAS UNIVen_US
dc.relation.ispartofKAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnastomotic Leakageen_US
dc.subjectColonic Anastomosisen_US
dc.subjectHydroxyprolineen_US
dc.subjectIschemia Reperfusion Injuryen_US
dc.subjectMesenchymal Stem Cellen_US
dc.titleThe healing effects of the topical mesenchymal stem cell application on colonic anastomosis subjected to ischemia reperfusion injuryen_US
dc.typeArticleen_US

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