The potential effects of ankaferd blood stopper and fibrin sealent on sleeve gastrectomy staple-line healing: An experimental study

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dc.authoridTuna Bilecik / 0000-0002-7160-2127
dc.authorscopusidTuna Bilecik / 55758337600
dc.authorwosidTuna Bilecik / ELH-9331-2022
dc.contributor.authorSakar, Alkan
dc.contributor.authorBilecik, Tuna
dc.contributor.authorMayir, Burhan
dc.contributor.authorOruc, Tahir
dc.date.accessioned2020-08-30T20:06:32Z
dc.date.available2020-08-30T20:06:32Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractStaple-line bleeding and leakage is a life-threatening complication in obese patients following laparoscopic sleeve gastrectomy. The aim of this study was to examine the potential effects of Ankaferd blood stopper (ABS) and Fibrin Sealant (FS; Tisseel (R)) on sleeve gastrectomy staple-line healing in an experimental animal model. A total of 30 Wistar albino female rats were divided into three groups and were subjected to sleeve gastrectomy with linear stapling. Group A (control group) had nothing administered, Group B was administered FS on the staple-line, and Group C was administered ABS on the staple-line following sleeve gastrectomy. After sacrifice on postoperative day 5, anastomotic burst pressure, tissue hydroxyproline levels and histopathological parameters were measured. The results revealed that group C had the highest mean bursting pressure level. However, the values of this parameter were not found to differ significantly between the groups (P>0.05). Group B and C had a similar hydroxyproline levels but increased compared with group A (P<0.001). Histopathological parameters were similar between the groups, except macrophage scores in group C. In the present experimental study, ABS was demonstrated to improve gastric-sleeved staple-line healing compared with FS. ABS may be used as a novel reinforcement agent in bariatric surgery.en_US
dc.identifier.citationSakar, A., Bilecik, T., Mayir, B., & Oruç, T. (2019). The potential effects of Ankaferd blood stopper and fibrin sealent on sleeve gastrectomy staple‑line healing: An experimental study. Experimental and therapeutic medicine, 18(4), 2519-2523.en_US
dc.identifier.doi10.3892/etm.2019.7842en_US
dc.identifier.endpage2523en_US
dc.identifier.issn1792-0981en_US
dc.identifier.issn1792-1015en_US
dc.identifier.issue4en_US
dc.identifier.pmid31555363en_US
dc.identifier.startpage2519en_US
dc.identifier.urihttps://doi.org/10.3892/etm.2019.7842
dc.identifier.urihttps://hdl.handle.net/20.500.12713/547
dc.identifier.volume18en_US
dc.identifier.wosWOS:000489717700021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBilecik, Tunaen_US
dc.language.isoenen_US
dc.publisherSpandidos Publ Ltden_US
dc.relation.ispartofExperimental and Therapeutic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObesityen_US
dc.subjectLaparoscopic Sleeve Gastrectomyen_US
dc.subjectAnkaferd Blood Stopperen_US
dc.subjectFibrin Sealenten_US
dc.titleThe potential effects of ankaferd blood stopper and fibrin sealent on sleeve gastrectomy staple-line healing: An experimental studyen_US
dc.typeArticleen_US

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