Healthcare resource utilization and direct costs of transfusion-dependent thalassemia patients in Dubai, United Arab Emirates: a retrospective cost-of-illness study

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dc.authoridHacer Özgen Narcı / 0000-0002-5666-2172en_US
dc.authorscopusidHacer Özgen Narcı / 57188552726
dc.authorwosidHacer Özgen Narcı / ADH-2166-2022
dc.contributor.authorAlshamsi, Shaikha
dc.contributor.authorHamidi, Samer
dc.contributor.authorÖzgen Narcı, Hacer
dc.date.accessioned2022-03-23T05:52:33Z
dc.date.available2022-03-23T05:52:33Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, İktisadi, İdari ve Sosyal Bilimler Fakültesi, Sağlık Yönetimi Bölümüen_US
dc.description.abstractBackground: Patients with transfusion-dependent thalassemia (TDT) require lifelong blood transfusions and iron chelation therapy. Thus, patients afflicted with TDT often have to undergo blood transfusion and iron chelation therapy, which causes a major economic burden on them. However, this topic has not been reported in Dubai, United Arab Emirates (UAE). Hence, this study aimed to evaluate healthcare resource utilization and associated direct costs related to patients with TDT in Dubai, UAE. Methods: For this study, a retrospective prevalence-based cost-of-illness analysis based on the UAE healthcare system and patient perspectives was conducted among patients with TDT treated at the Dubai Thalassemia Center in 2019. Information regarding healthcare resource utilization and direct medical costs was collected from the billing system connected to the electronic medical record system. Patients and their families were interviewed for direct non-medical cost estimations. Results: A total of 255 patients with TDT were included in the study. The mean annual direct medical cost was estimated at AED 131,156 (USD 35,713) (95% CI: 124,735 - 137,578). The main driver of the medical cost for the participants as iron chelation therapy AED 78,372 (95% CI: 72,671 - 84,074) (59.8%), followed by blood transfusions, which accounted for AED 34,223 (95% CI: 32,854 - 35,593) 26.1% of the total direct medical costs. The mean annual direct non-medical costs was AED 2,223 (USD 605) (95% CI: 1,946 - 2,500). Age (p < 0.001), severe serum ferritin levels (p = 0.016), the presence of complications (p < 0.001), and the type of iron chelation therapy (p < 0.001) were significant predictors of higher direct medical costs incurred by the participants. Conclusion: Transfusion-dependent thalassemia poses a substantial economic burden on the healthcare system, patients, and their families. Our results show that the highest medical cost proportion was due to iron chelation therapy. In this regard, efforts must be made to improve the patients' acceptance and satisfaction with their iron chelation therapy to increase their compliance and improve the effectiveness of treatment, which could play an essential role in controlling the economic burden of this disease. Moreover, greater support is essential for families that suffer catastrophic out-of-pocket expenses.en_US
dc.identifier.citationAlshamsi S, Hamidi S, Narci HO. Healthcare resource utilization and direct costs of transfusion-dependent thalassemia patients in Dubai, United Arab Emirates: a retrospective cost-of-illness study. BMC Health Serv Res. 2022 Mar 5;22(1):304.en_US
dc.identifier.doi10.1186/s12913-022-07663-6en_US
dc.identifier.issue1en_US
dc.identifier.pmid35248046en_US
dc.identifier.scopus2-s2.0-85125846184en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage304en_US
dc.identifier.urihttps://doi.org/10.1186/s12913-022-07663-6
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2569
dc.identifier.volume22en_US
dc.identifier.wosWOS:000765011300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzgen Narcı, Hacer
dc.language.isoenen_US
dc.relation.ispartofBMC Health Serv Res.en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDirect Costsen_US
dc.subjectDubaien_US
dc.subjectHealth Policyen_US
dc.subjectHealthcare Resource Utilizationen_US
dc.subjectTransfusion-dependent Thalassemiaen_US
dc.subjectUnited Arab Emiratesen_US
dc.titleHealthcare resource utilization and direct costs of transfusion-dependent thalassemia patients in Dubai, United Arab Emirates: a retrospective cost-of-illness studyen_US
dc.typeArticleen_US

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