Lighting up the tumor-fluorescein-guided resection of gangliogliomas

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dc.authoridTalat Kırış / 0000-0002-2985-3758
dc.authoridMehmet Osman Akçakaya / 0000-0001-8617-202X
dc.authorscopusidMehmet Osman Akçakaya / 57241760900
dc.authorscopusidTalat Kırış / 6602747157
dc.authorwosidMehmet Osman Akçakaya / HTG-8644-2023
dc.authorwosidTalat Kırış / AAP-4665-2020
dc.contributor.authorHoehne, Julius
dc.contributor.authorAcerbi, Francesco
dc.contributor.authorFalco, Jacopo
dc.contributor.authorAkçakaya, Mehmet Osman
dc.contributor.authorSchmidt, Nils Ole
dc.contributor.authorKiriş, Talat
dc.contributor.authorde Laurentis, Camilla
dc.contributor.authorFerroli, Paolo
dc.contributor.authorBroggi, Morgan
dc.contributor.authorSchebesch, Karl-Michael
dc.date.accessioned2020-09-22T06:42:20Z
dc.date.available2020-09-22T06:42:20Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstract(1) Background: Gangliogliomas comprise a small number of brain tumors. They usually present as World Health Organization (WHO) grade I, and they delineate on gadolinium-enhanced MRI; the surgical goal is wide radical resection, and the course thereafter is usually benign. Fluorescein sodium (FL) tends to accumulate in areas with altered blood-brain barrier (BBB). Thus far, the results provided by prospective and retrospective studies show that the utilization of this fluorophore may be associated with better visualization and improvement of resection for several tumors of the central nervous system. In this study, we retrospectively studied the effect of fluorescein sodium on visualization and resection of gangliogliomas. (2) Methods: Surgical databases in three neurosurgical departments (Regensburg University Hospital; Besta Institute, Milano, Italy; and Liv Hospital, Istanbul, Turkey), with approval by the local ethics committee, were retrospectively reviewed to find gangliogliomas surgically removed by a fluorescein-guided technique by the aid of a dedicated filter on the surgical microscope from April 2014 to February 2020. Eighteen patients (13 women, 5 men; mean age 22.9 years, range 3 to 78 years) underwent surgical treatment for gangliogliomas during 19 operations. Fluorescein was intravenously injected (5 mg/kg) after general anesthesia induction. Tumors were removed using a microsurgical technique with the YELLOW 560 Filter (YE560) (KINEVO/PENTERO 900, Carl Zeiss Meditec, Oberkochen, Germany). (3) Results: No side effects related to fluorescein occurred. In all tumors, contrast enhancement on preoperative MRI correlated with bright yellow fluorescence during the surgical procedure (17 gangliogliomas WHO grade I, 1 ganglioglioma WHO grade II). Fluorescein was considered helpful by the operating surgeon in distinguishing tumors from viable tissue in all cases (100%). Biopsy was intended in two operations, and subtotal resection was intended in one operation. In all other operations considered preoperatively eligible, gross total resection (GTR) was achieved in 12 out of 16 (75%) instances. (4) Conclusions: The use of FL and YE560 is a readily available method for safe fluorescence-guided tumor resection, possibly visualizing tumor margins intraoperatively similar to contrast enhancement in T1-weighted MRI. Our data suggested a positive effect of fluorescein-guided surgery on intraoperative visualization and extent of resection during resection of gangliogliomas.en_US
dc.identifier.citationHöhne, J., Acerbi, F., Falco, J., Akçakaya, M. O., Schmidt, N. O., Kiris, T., ... & Schebesch, K. M. (2020). Lighting Up the Tumor—Fluorescein-Guided Resection of Gangliogliomas. Journal of Clinical Medicine, 9(8), 2405.en_US
dc.identifier.doi10.3390/jcm9082405en_US
dc.identifier.issn2077-0383en_US
dc.identifier.issue8en_US
dc.identifier.pmid32731376en_US
dc.identifier.scopus2-s2.0-85097618588en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/jcm9082405
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1060
dc.identifier.volume9en_US
dc.identifier.wosWOS:000567100100001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAkçakaya, Mehmet Osman
dc.institutionauthorKırış, Talat
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofJOURNAL OF CLINICAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGangliogliomaen_US
dc.subjectFluorescein Sodiumen_US
dc.subjectYELLOW 560 nm Filteren_US
dc.subjectFluorescence-Guided Surgeryen_US
dc.subjectPENTERO 900en_US
dc.subjectKINEVOen_US
dc.subjectSurgical Microscopeen_US
dc.subjectNeurosurgeryen_US
dc.subjectSurgical Microscope Filteren_US
dc.subjectCentral-Nervous-Systemen_US
dc.subjectSodium Fluoresceinen_US
dc.subjectBrainen_US
dc.subjectGliomasen_US
dc.titleLighting up the tumor-fluorescein-guided resection of gangliogliomasen_US
dc.typeArticleen_US

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