Cervical cancer progression is regulated by SOX transcription factors: Revealing signaling networks and therapeutic strategies

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorPaskeh, Mahshid Deldar Abad
dc.contributor.authorMirzaei, Sepideh
dc.contributor.authorGholami, Mohammad Hossein
dc.contributor.authorZarrabi, Ali
dc.contributor.authorZabolian, Amirhossein
dc.contributor.authorHashemi, Mehrdad
dc.contributor.authorHushmandi, Kiavash
dc.date.accessioned2021-11-08T11:12:34Z
dc.date.available2021-11-08T11:12:34Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractCervical cancer is the fourth common gynecologic cancer and is considered as second leading cause of death among women. Various strategies are applied in treatment of cervical cancer including radiotherapy, chemotherapy and surgery. However, cervical cancer cells demonstrate aggressive behavior in advanced phases, requiring novel strategies in their elimination. On the other hand, SOX proteins are transcription factors capable of regulating different molecular pathways and their expression varies during embryogenesis, disease development and carcinogenesis. In the present review, our aim is to reveal role of SOX transcription factors in cervical cancer. SOX transcription factors play like a double-edged sword in cancer. For instance, SOX9 possesses both tumor-suppressor and tumor-promoting role in cervical cancer. Therefore, exact role of each SOX members in cervical cancer has been discussed to direct further experiments for revealing other functions. SOX proteins can regulate proliferation and metastasis of cervical cancer cells. Furthermore, response of cervical cancer cells to chemotherapy and radiotherapy is tightly regulated by SOX transcription factors. Different downstream targets of SOX proteins such as Wnt signaling, EMT and Hedgehog have been identified. Besides, upstream mediators such as microRNAs, lncRNAs and circRNAs can regulate SOX expression in cervical cancer. In addition to pre-clinical studies, role of SOX transcription factors as prognostic and diagnostic tools in cervical cancer has been shown.en_US
dc.identifier.citationPaskeh, M., Mirzaei, S., Gholami, M. H., Zarrabi, A., Zabolian, A., Hashemi, M., Hushmandi, K., Ashrafizadeh, M., Aref, A. R., & Samarghandian, S. (2021). Cervical cancer progression is regulated by SOX transcription factors: Revealing signaling networks and therapeutic strategies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 144, 112335. Advance online publication. https://doi.org/10.1016/j.biopha.2021.112335en_US
dc.identifier.doi10.1016/j.biopha.2021.112335en_US
dc.identifier.issue112335en_US
dc.identifier.pmid34700233en_US
dc.identifier.scopus2-s2.0-85117707036en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2021.112335
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2212
dc.identifier.volume144en_US
dc.identifier.wosWOS:000712594700007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.relation.ispartofBiomedicine & Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiomarkeren_US
dc.subjectCancer Therapyen_US
dc.subjectCervical Canceren_US
dc.subjectChemoresistanceen_US
dc.subjectNon-coding RNAsen_US
dc.subjectSOX Transcription Factoren_US
dc.titleCervical cancer progression is regulated by SOX transcription factors: Revealing signaling networks and therapeutic strategiesen_US
dc.typeReview Articleen_US

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