The real-world experience with single agent ibrutinib in relapsed/refractory CLL

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Küçük Resim

Tarih

2021

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Elsevier

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

ntroduction/background: The emergence of novel agents targeting the B-cell receptor pathway and BCL-2 has significantly changed the therapeutic landscape of CLL. We evaluated the safety and efficacy of single-agent ibrutinib in relapsed/refractory CLL in real-world settings. Patients/methods: A total of 200 relapsed/refractory CLL patients with a median age of 68 were included in this retrospective, multicenter, non-interventional study. Data of the study were captured from the patient charts of the participating centers. Results: The median for lines of previous chemotherapy was 2 (1-6); 62 (31.8%) patients had del17p and/or p53 mutations (del17p+/p53mut). Of the study group, 146 (75%) patients achieved at least PR, while 16 (8.7%) patients discontinued ibrutinib due to TEA. The most common drug-related adverse events were neutropenia (n: 31; 17.4%) and thrombocytopenia (n: 40; 22.3%), which were ? grade 3 in 9 (5%) and 5 (3.9%) patients, respectively. Pneumonia (n: 42; 23.7%) was the most common nonhematologic TEA. Atrial fibrillation (n: 5; 2.8%) and bleeding (n: 11; 6.3%) were relatively rare during the study period. Within a median follow-up period of 17 (1-74) months, 42 (21%) patients died. The estimated median OS of the study cohort was 52 months. Only the response to ibrutinib (CR/PR vs. SD/PD) was significantly associated with OS.

Açıklama

Anahtar Kelimeler

Bruton Tyrosine Kinase, Chronic Lymphocytic Leukemia, Ibrutinib, Relapsed/refractory, P53 Mutation

Kaynak

Clinical Lymphoma, Myeloma and Leukemia

WoS Q Değeri

Q3

Scopus Q Değeri

N/A

Cilt

Sayı

Künye

Akpinar, S., Dogu, M. H., Celik, S., Ekinci, O., Hindilerden, I. Y., Dal, M. S., Davulcu, E. A., Tekinalp, A., Hindilerden, F., Ozcan, B. G., Hacibekiroglu, T., Erkurt, M. A., Bagci, M., Namdaroglu, S., Korkmaz, G., Bilgir, O., Cagliyan, G. A., Ozturk, H., Serin, I., Tiryaki, T. O., … Altuntas, F. (2021). The Real-World Experience With Single Agent Ibrutinib in Relapsed/Refractory CLL. Clinical lymphoma, myeloma & leukemia, S2152-2650(21)02040-1. Advance online publication.