Agomelatine is superior to melatonin in pain suppression: an experimental study

Basit Öğe Kaydı
dc.authoridMehmet Ferit İsbir / 0000-0001-5621-5674
dc.authorwosidMehmet Ferit İsbir / ILH-1510-2023
dc.contributor.authorYücel, Ali Okan
dc.contributor.authorDemir-Dora, Devrim
dc.contributor.authorİsbir, Mehmet Ferit
dc.contributor.authorDora, Babur
dc.date.accessioned2021-01-28T11:08:47Z
dc.date.available2021-01-28T11:08:47Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractObjective: Agomelatine is a synthetic analog of melatonin with selective agonist action on melatonin MT1 and MT2 receptors and antagonistic effect on serotonin 5HT2c receptors. Similar to melatonin, it also has antinociceptive properties. There are only a few studies comparing the antinociceptive effects of agomelatine to melatonin. Methods: Male Wistar albino rats were grouped into seven treatment groups and a control group (8 animals each). Treatment groups received intraperitoneal injections of agomelatine 25 mg/kg, 35 mg/kg and 50 mg/kg; agomelatine 35 mg/kg + luzindole 10 mg/kg; melatonin 60 mg/kg and 90 mg/ kg and melatonin 60 mg/kg + sertraline 10 mg/kg. Animals were placed on a hot plate and time to pain avoidance behavior was measured. Results: Agomelatine 25 mg/kg, 35 mg/kg and 50 mg/kg were significantly superior to placebo (all p < 0.0001); agomelatine 35 mg/kg and 50 mg/kg were significantly superior to melatonin 60 mg/kg (p < 0.05 and p < 0.01, respectively) and melatonin 90 mg/kg (p < 0.001 and p < 0.001, respectively) in prolonging reaction times. Agomelatine 50 mg/kg was superior to melatonin 60 mg/kg + sertraline 10 mg/ kg (p < 0,05); on the contrary; agomelatine 25 mg/kg was significantly inferior to this combination in prolonging reaction times (p = 0,041). Melatonin 90 mg/ kg but not 60 mg/kg was significantly superior to placebo in prolonging reaction times (p < 0.0001). Both agomelatine 50 mg/kg and 35 mg/kg were superior to agomelatine 25 mg/kg (p < 0.0001 and p = 0.002, respectively), but the difference between agomelatine 50 mg/kg and 35 mg/kg was not significant. Conclusions: We demonstrated that agomelatine is superior to melatonin on pain behavior in a dose-dependent manner using an experimental pain model. The addition of a serotonergic agent increased the antinociceptive effect of melatonin in regard to agomelatine, but high doses of agomelatine were still more effective, suggesting a dose-dependent effect of agomelatine on 5-HT2c receptors.en_US
dc.identifier.citationYucel, A. O., Demir-Dora, D., İsbir, M. F., & Dora, B. (2020). Agomelatine is superior to melatonin in pain suppression: An experimental study. Neurological Sciences and Neurophysiology, 37(4), 203.en_US
dc.identifier.doi10.4103/NSN.NSN_49_20en_US
dc.identifier.endpage207en_US
dc.identifier.issn2636-865Xen_US
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85099533912en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage203en_US
dc.identifier.trdizinid413846en_US
dc.identifier.urihttps://www.doi.org/10.4103/NSN.NSN_49_20
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1379
dc.identifier.volume37en_US
dc.identifier.wosWOS:000607818400008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorİsbir, Mehmet Ferit
dc.language.isoenen_US
dc.publisherAVESen_US
dc.relation.ispartofNeurological Sciences and Neurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject5 HT2c Receptoren_US
dc.subjectAgomelatineen_US
dc.subjectMelatoninen_US
dc.subjectNociceptionen_US
dc.subjectPainen_US
dc.subjectSerotoninen_US
dc.titleAgomelatine is superior to melatonin in pain suppression: an experimental studyen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
isbir1.pdf
Boyut:
1.32 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Eczacılık Meslek Bilimleri Bölümü Makale Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu