Changing presentation of acromegaly in half a century: a single-center experience

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dc.authoridDemir, Ahmet Numan/0000-0002-9997-7051
dc.authoridKadioglu, Pinar/0000-0002-8329-140X
dc.authorwosidDemir, Ahmet Numan/AEK-2338-2022
dc.authorwosidKadioglu, Pinar/AAM-9935-2020
dc.contributor.authorDemir, Ahmet Numan
dc.contributor.authorSulu, Cem
dc.contributor.authorKara, Zehra
dc.contributor.authorSahin, Serdar
dc.contributor.authorOzaydin, Dilan
dc.contributor.authorSonmez, Ozge
dc.contributor.authorKeskin, Fatma Ela
dc.date.accessioned2024-05-19T14:38:48Z
dc.date.available2024-05-19T14:38:48Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjectiveInvestigate the changes in the characteristics of presentation, in patients with acromegaly over a period of approximately half a century.MethodsThe medical records of patients diagnosed with acromegaly between 1980 and 2023 were retrospectively reviewed. The collected data were examined to assess any changes observed over the years and a comparison was made between the characteristics of patients diagnosed in the last decade and those diagnosed in previous years.ResultsA total of 570 patients were included in the study, 210 (37%) patients were diagnosed in the last decade. Patients diagnosed before 2014 had longer symptom duration before diagnosis, advanced age, larger pituitary adenomas, higher incidence of cavernous sinus invasion, and higher GH and IGF-1 levels than those diagnosed last decade (p < 0.05, for all). Furthermore, the patients diagnosed before 2014 had a lower rate of surgical remission (p < 0.001), and a higher prevalence of comorbidities such as diabetes, hypertension, colon polyps, and thyroid cancer at the time of diagnosis (p < 0.05, for all).ConclusionThere may be a trend for earlier detection of patients with acromegaly.en_US
dc.identifier.doi10.1007/s11102-023-01344-1
dc.identifier.endpage582en_US
dc.identifier.issn1386-341X
dc.identifier.issn1573-7403
dc.identifier.issue5en_US
dc.identifier.pmid37523026en_US
dc.identifier.scopus2-s2.0-85166173513en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage573en_US
dc.identifier.urihttps://doi.org10.1007/s11102-023-01344-1
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4610
dc.identifier.volume26en_US
dc.identifier.wosWOS:001040168600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPituitaryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAcromegalyen_US
dc.subjectComorbidityen_US
dc.subjectDiagnosisen_US
dc.subjectPresentationen_US
dc.titleChanging presentation of acromegaly in half a century: a single-center experienceen_US
dc.typeArticleen_US

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