Modular nanotheranostic agents for protistan parasitic diseases: Magic bullets with tracers

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dc.authoridKhan, Naveed/0000-0001-7667-8553
dc.authoridSiddiqui, Ruqaiyyah/0000-0001-9646-6208
dc.authoridMaciver, Sutherland Kester/0000-0001-8234-6061
dc.authorwosidKhan, Naveed/AAM-2892-2021
dc.authorwosidKhan, Naveed/KCK-0156-2024
dc.authorwosidSiddiqui, Ruqaiyyah/AIF-2100-2022
dc.authorwosidMaciver, Sutherland Kester/H-6284-2019
dc.contributor.authorMaciver, Sutherland Kester
dc.contributor.authorAbdelnasir, Sumayah
dc.contributor.authorAnwar, Ayaz
dc.contributor.authorSiddiqui, Ruqaiyyah
dc.contributor.authorKhan, Naveed Ahmed
dc.date.accessioned2024-05-19T14:45:57Z
dc.date.available2024-05-19T14:45:57Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractProtistan parasitic infections contribute significantly to morbidity and mortality, causing more than 2 billion human infections annually. However, current treatments are often limited; due to ineffective drugs and drug resistance, thus better options are urgently required. In the present context, theranostics agents are those that offer simultaneous detection, diagnosis and even treatment of protistan parasitic diseases. Nanotheranostics is the term used to describe such agents, that are around 100 nm or less in size. Anti-parasitic activity of nanoparticles (NPs) has been reported, and many have useful intrinsic imaging properties, but it is perhaps their multifunctional nature that offers the greatest potential. NPs may be used as adapters onto which various subunits with different functions may be attached. These subunits may facilitate targeting parasites, coupled with toxins to eradicate parasites, and probe subunits for detection of particles and/or parasites. The modular nature of nano-platforms promises a mix and match approach for the construction of tailored agents by using combinations of these subunits against different protistan parasites. Even though many of the subunits have shown promise alone, these have not yet been put together convincingly enough to form working theranostics against protistan parasites. Although the clinical application of nanotheranostics to protistan parasitic infections in humans requires more research, we conclude that they offer not just a realisation of Paul Ehrlich's long imagined magic bullet concept, but potentially are magic bullets combined with tracer bullets.en_US
dc.identifier.doi10.1016/j.molbiopara.2022.111541
dc.identifier.issn0166-6851
dc.identifier.issn1872-9428
dc.identifier.pmid36603708en_US
dc.identifier.scopus2-s2.0-85146464743en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org10.1016/j.molbiopara.2022.111541
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5403
dc.identifier.volume253en_US
dc.identifier.wosWOS:000990574300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMolecular and Biochemical Parasitologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectNanotheranosticsen_US
dc.subjectNanoparticlesen_US
dc.subjectQuantum Dotsen_US
dc.subjectLiposomesen_US
dc.subjectParasitesen_US
dc.subjectMalariaen_US
dc.subjectLeishmaniasisen_US
dc.subjectTrypanosomiasisen_US
dc.subjectAmoebaeen_US
dc.titleModular nanotheranostic agents for protistan parasitic diseases: Magic bullets with tracersen_US
dc.typeReview Articleen_US

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