Comparison of hematopoietic stem cell transplantation results in patients with ?-thalassemia major from three different graft types

Basit Öğe Kaydı
dc.authoridBaşaklı Adaklı Aksoy / 0000-0001-8338-2101en_US
dc.authoridCeyhun Bozkurt / 0000-0001-6771-9894en_US
dc.authorscopusidCeyhun Bozkurt / 6602784315
dc.authorscopusidBaşak Adaklı Aksoy / 8960776700
dc.authorwosidBaşak Adaklı Aksoy / AAK-3627-2021
dc.authorwosidCeyhun Bozkurt / AAL-5043-2021
dc.contributor.authorAydoğdu, Selime
dc.contributor.authorTöret, Ersin
dc.contributor.authorAdaklı Aksoy, Başak
dc.contributor.authorAydın, Muhammed Fatih
dc.contributor.authorErol Cipe, Funda
dc.contributor.authorBozkurt, Ceyhun
dc.contributor.authorFışgın, Tunç
dc.date.accessioned2021-01-26T07:04:18Z
dc.date.available2021-01-26T07:04:18Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAllogeneic hematopoietic stem cell transplantation (HSCT) is the curative therapy for ?-thalassemias that induces severe life-threatening complications. The human leukocyte antigen (HLA) registries and umbilical cord blood banks have carried out diligent searches to find matched unrelated donors (MUDs) for about 70.0% of patients from 2000 onwards. The chance of finding a non-sibling fully matched family donors is higher in some ethnic groups in which consanguineous marriages are common. We have studied and compared transplant complications and outcomes in different graft types (sibling, non-sibling family and unrelated). The non-sibling matched family donor (MFD) group consisted of four mothers, three fathers, five cousins, one paternal uncle and one paternal aunt. There was no significant difference in the mean transfused CD34+ cells, engraftment, median days of neutrophil and platelet recovery were achieved (p?>?0.05). The distribution of postttransplant complication did not show any significant difference between groups (p?>?0.05). In univariate analysis and multivarite analyses, age, gender, Pesaro risk group (I-II vs. III) and ABO incompatibilty demonstrated a significant difference in disease free survival (p?<?0.05). Furthermore, in the second step of investigating overall survival (OS), age, gender and Pesaro risk group (I-II vs. III) showed a significant difference (p?<?0.05). There was no significant difference in transplant-related mortality (TRM) between groups. Non-sibling related donor transplants are important for populations where consanguineous marriages are common. Transplant groups according to graft type had similar thalassemia-free survival (TFS) and OS when using a treosulfan-based regimen in our study.en_US
dc.identifier.citationAydogdu, S., Toret, E., Aksoy, B. A., Aydın, M. F., Cipe, F. E., Bozkurt, C., & Fisgin, T. (2021). Comparison of Hematopoietic Stem Cell Transplantation Results in Patients with β-Thalassemia Major from Three Different Graft Types. Hemoglobin, 1–10. Advance online publication. https://doi.org/10.1080/03630269.2021.1872611en_US
dc.identifier.doi10.1080/03630269.2021.1872611en_US
dc.identifier.endpage10en_US
dc.identifier.issn0363-0269en_US
dc.identifier.issn1532-432Xen_US
dc.identifier.issue21en_US
dc.identifier.pmid33478286en_US
dc.identifier.scopus2-s2.0-85099909459en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1080/03630269.2021.1872611
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1376
dc.identifier.wosWOS:000611144500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAdaklı Aksoy, Başak
dc.institutionauthorBozkurt, Ceyhun
dc.language.isoenen_US
dc.publisherTaylor & Francis Onlineen_US
dc.relation.ispartofHemoglobinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHematopoietic Stem Cell Transplantation (HSCT)en_US
dc.subjectNon-Sibling Family Donoren_US
dc.subjectPediatricsen_US
dc.subjectThalassemiaen_US
dc.subjectTreosulfanen_US
dc.titleComparison of hematopoietic stem cell transplantation results in patients with ?-thalassemia major from three different graft typesen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
10.pdf
Boyut:
1.25 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/ Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PubMed İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu