Can concurrent high-risk endometrial carcinoma occur with atypical endometrial hyperplasia?

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dc.authoridNuri Peker / 0000-0002-4854-3851
dc.authorscopusidNuri Peker / 55258922800
dc.authorwosidNuri Peker / FWE-6871-2022
dc.contributor.authorErdem, Baki
dc.contributor.authorAşıcıoğlu, Osman
dc.contributor.authorSeyhan, Niyazi Alper
dc.contributor.authorPeker, Nuri
dc.contributor.authorÜlker, Volkan
dc.contributor.authorAkbayır, Özgür
dc.date.accessioned2020-08-30T20:07:34Z
dc.date.available2020-08-30T20:07:34Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractBackground: This study investigated the frequency of high-risk cancer types in hysterectomy material obtained from patients who were diagnosed with atypical endometrial hyperplasia (AEH) by endometrial sampling. Materials and methods: A total of 227 patients with AEH were retrospectively included in the study. Hysterectomy material was examined as both perioperative frozen section (FS) and paraffin-embedded permanent section (PS). Grade III tumors, grade II tumors larger than 2 cm, over 50% myometrial invasion, cervical involvement, and serous or clear cell histology were considered high-risk. Results: In final pathology, 57 (25.1%) patients had endometrial cancer and 7 (3%) patients had high-risk cancer. Overall analysis of FS/PS agreement yielded a Cohen's Kappa (K) coefficient of 0.420 (moderate agreement). There was moderate (K=0.526) agreement between FS and PS in detecting tumor grade, and good agreement (K=0.653) in evaluation of myometrial invasion. Conclusion: High-risk endometrial cancer can coexist with AEH. It should be remembered that despite pre-operative and FS examinations, these high-risk tumors can be overlooked until final pathology.en_US
dc.identifier.citationErdem, B., Aşıcıoğlu, O., Seyhan, N. A., Peker, N., Ülker, V., & Akbayır, Ö. (2018). Can concurrent high-risk endometrial carcinoma occur with atypical endometrial hyperplasia?. International Journal of Surgery, 53, 350-353.en_US
dc.identifier.doi10.1016/j.ijsu.2018.04.019en_US
dc.identifier.endpage353en_US
dc.identifier.issn1743-9191en_US
dc.identifier.issn1743-9159en_US
dc.identifier.pmid29665453en_US
dc.identifier.scopus2-s2.0-85045706824en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage350en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijsu.2018.04.019
dc.identifier.urihttps://hdl.handle.net/20.500.12713/792
dc.identifier.volume53en_US
dc.identifier.wosWOS:000432654400054en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorPeker, Nurien_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofInternational Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtypical Endometrial Hyperplasiaen_US
dc.subjectEndometrial Canceren_US
dc.subjectFrozen Sectionen_US
dc.titleCan concurrent high-risk endometrial carcinoma occur with atypical endometrial hyperplasia?en_US
dc.typeArticleen_US

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