Olfactory ensheathing cells: unique glial cells promising for treatments of spinal cord injury

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dc.authoridErdal Karaöz / 0000-0002-9992-833Xen_US
dc.authoridHakan Darıcı / 0000-0001-9393-554X
dc.authoridSelin Ursavaş / 0000-0002-6727-9048
dc.authorscopusidErdal Karaöz / 7003448087
dc.authorscopusidHakan Darıcı / 22333489600
dc.authorwosidErdal Karaöz / JJU-1133-2023
dc.authorwosidHakan Darıcı / AAG-4316-2019
dc.authorwosidSelin Ursavaş / AAO-2823-2020
dc.contributor.authorUrsavaş, Selin
dc.contributor.authorDarıcı, Hakan
dc.contributor.authorKaraöz, Erdal
dc.date.accessioned2021-02-22T11:56:08Z
dc.date.available2021-02-22T11:56:08Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractSpinal cord injury (SCI) is generally the consequence of physical damage, which may result in devastating consequences such as paraplegia or paralysis. Some certain candidates for SCI repair are olfactory ensheathing cells (OECs), which are unique glial cells located in the transition region of the peripheral nervous system and central nervous system and perform neuron regeneration in the olfactory system throughout life. Culture studies have clarified many properties of OECs, but their mechanisms of actions are not fully understood. Successful results achieved in animal models showcased that SCI treatment with OEC transplants is suitable for clinical tri-als. However, clinical trials are limited by difficulties like cell acquisition for autograft transplantation. Despite the improvements in both animal and clinical studies so far, there is still insufficient information about the mechanism of actions, adverse effects, proper application methods, effective subtypes, and sources of cells. This review summarizes pre- clinical and clinical literature focused on the cellular characterization of both OECs in vitro and post- transplantation. We highlight the roles and effects of OECs on (a) the injury- induced glial milieu, (b) neuronal growth/regeneration, and (c) functional recovery after injury. Due to the shown benefits of OECs with in vitro and animal studies and a limited number of clinical trials, where safety and effectivity were shown, it is necessary to conduct more studies on OECs to obtain effective and feasible treatment methods.en_US
dc.identifier.citationUrsavas, S., Darici, H., & Karaoz, E. (2021). Olfactory ensheathing cells: Unique glial cells promising for treatments of spinal cord injury. Journal of neuroscience research, 10.1002/jnr.24817. Advance online publication. https://doi.org/10.1002/jnr.24817en_US
dc.identifier.doi10.1002/jnr.24817en_US
dc.identifier.pmid33605466en_US
dc.identifier.scopus2-s2.0-85101034979en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1002/jnr.24817
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1488
dc.identifier.wosWOS:000619501900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUrsavaş, Selin
dc.institutionauthorDarıcı, Hakan
dc.institutionauthorKaraöz, Erdal
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJ Neurosci Res.en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlial Cellsen_US
dc.subjectOlfactory Ensheathing Cellsen_US
dc.subjectRegenerative Medicineen_US
dc.subjectSpinal Cord Injuryen_US
dc.subjectThe Olfactory Systemen_US
dc.titleOlfactory ensheathing cells: unique glial cells promising for treatments of spinal cord injuryen_US
dc.typeReview Articleen_US

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