Spinal cord injury management through the combination of stem cells and implantable 3d bioprinted platforms

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dc.authoridAli Zarrabi / 0000-0003-0391-1769
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorZarepour A.
dc.contributor.authorHooshmand S.
dc.contributor.authorGökmen A.
dc.contributor.authorZarrabi A.
dc.contributor.authorMostafavi E.
dc.date.accessioned2021-11-23T06:18:14Z
dc.date.available2021-11-23T06:18:14Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractSpinal cord injury (SCI) has a major impact on affected patients due to its pathological consequences and absence of capacity for self-repair. Currently available therapies are unable to restore lost neural functions. Thus, there is a pressing need to develop novel treatments that will promote functional repair after SCI. Several experimental approaches have been explored to tackle SCI, including the combination of stem cells and 3D bioprinting. Implanted multipotent stem cells with self-renewing capacity and the ability to differentiate to a diversity of cell types are promising candidates for replacing dead cells in injured sites and restoring disrupted neural circuits. However, implanted stem cells need protection from the inflammatory agents in the injured area and support to guide them to appropriate differentiation. Not only are 3D bioprinted scaffolds able to protect stem cells, but they can also promote their differentiation and functional integration at the site of injury. In this review, we showcase some recent advances in the use of stem cells for the treatment of SCI, different types of 3D bioprinting methods, and the combined application of stem cells and 3D bioprinting technique for effective repair of SCI.en_US
dc.identifier.citationZarepour, A., Hooshmand, S., Gökmen, A., Zarrabi, A., & Mostafavi, E. (2021). Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms. Cells, 10(11), 3189.en_US
dc.identifier.doi10.3390/cells10113189en_US
dc.identifier.issn2073-4409en_US
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85118976426en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.uriuri:https://doi.org/10.3390/cells10113189
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2272
dc.identifier.volume10en_US
dc.identifier.wosWOS:000727841500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofCellsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject3D Bioprintingen_US
dc.subjectNeural Tissue Engineeringen_US
dc.subjectSpinal Cord Injuryen_US
dc.subjectStem Cellsen_US
dc.subjectTissue Regenerationen_US
dc.titleSpinal cord injury management through the combination of stem cells and implantable 3d bioprinted platformsen_US
dc.typeReview Articleen_US

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