Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response

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dc.authoridZarrabi, Ali/0000-0003-0391-1769
dc.authoridSethi, Gautam/0000-0002-8677-8475
dc.authorwosidZarrabi, Ali/U-2602-2019
dc.authorwosidSethi, Gautam/F-2372-2011
dc.contributor.authorAshrafizadeh, Milad
dc.contributor.authorMohan, Chakrabhavi D.
dc.contributor.authorRangappa, Shobith
dc.contributor.authorZarrabi, Ali
dc.contributor.authorHushmandi, Kiavash
dc.contributor.authorKumar, Alan Prem
dc.contributor.authorSethi, Gautam
dc.date.accessioned2024-05-19T14:40:06Z
dc.date.available2024-05-19T14:40:06Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractGastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic transcription factor that promotes the transcription of genes associated with proliferation, antiapoptosis, survival, and metastasis. STAT3 is overactivated in many human malignancies including GI tumors which accelerates tumor progression, metastasis, and drug resistance. Research in recent years demonstrated that noncoding RNAs (ncRNAs) play a major role in the regulation of many signaling pathways including the STAT3 pathway. The major types of endogenous ncRNAs that are being extensively studied in oncology are microRNAs, long noncoding RNAs, and circular RNAs. These ncRNAs can either be tumor-promoters or tumor-suppressors and each one of them imparts their activity via different mechanisms. The STAT3 pathway is also tightly modulated by ncRNAs. In this article, we have elaborated on the tumor-promoting role of STAT3 signaling in GI tumors. Subsequently, we have comprehensively discussed the oncogenic as well as tumor suppressor functions and mechanism of action of ncRNAs that are known to modulate STAT3 signaling in GI cancers.en_US
dc.description.sponsorshipSingapore Ministry of Education Tier 2 [MOE-T2EP30120-0016]; National Medical Research Council of Singapore; Singapore Ministry of Education; National University of Singapore; Council of Scientific and Industrial Research; Indian Science Congress Associationen_US
dc.description.sponsorshipSingapore Ministry of Education Tier 2, Grant/Award Number: MOE-T2EP30120-0016;National Medical Research Council of Singapore; Singapore Ministry of Education; Council of Scientific and Industrial Research; Indian Science Congress Associationen_US
dc.identifier.doi10.1002/med.21950
dc.identifier.endpage1321en_US
dc.identifier.issn0198-6325
dc.identifier.issn1098-1128
dc.identifier.issue5en_US
dc.identifier.pmid36951271en_US
dc.identifier.scopus2-s2.0-85151000323en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1263en_US
dc.identifier.urihttps://doi.org10.1002/med.21950
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4907
dc.identifier.volume43en_US
dc.identifier.wosWOS:000955092900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofMedicinal Research Reviewsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCircrnaen_US
dc.subjectColorectal Canceren_US
dc.subjectEsophageal Canceren_US
dc.subjectGastric Canceren_US
dc.subjectLiver Canceren_US
dc.subjectLncrnaen_US
dc.subjectMirnaen_US
dc.subjectPancreatic Canceren_US
dc.titleNoncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic responseen_US
dc.typeReview Articleen_US

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