Penicillin and oxacillin loaded on pegylated-graphene oxide to enhance the activity of the antibiotics against methicillin-resistant staphylococcus aureus

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dc.authoridAtefeh Zarepour / 0000-0002-0347-5840en_US
dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorscopusidAtefeh Zarepour / 56700291100
dc.authorwosidAtefeh Zarepour / DZE-4304-2022en_US
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.contributor.authorZarepour, Atefeh
dc.contributor.authorZarrabi, Ali
dc.contributor.authorTabar, Mohadeseh Mohammadi
dc.contributor.authorKhaleghi, Moj
dc.contributor.authorBidram, Elham
dc.date.accessioned2022-11-12T07:19:58Z
dc.date.available2022-11-12T07:19:58Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractInfectious diseases are known as the second biggest cause of death worldwide, due to the development of antibiotic resistance. To overcome this problem, nanotechnology offers some promising approaches, such as drug delivery systems that can enhance drug efficiency. Herein, a Graphene Oxide-polyethylene glycol (GO-PEG) nano-platform was synthesized and penicillin and oxacillin, two antibiotics that are ineffective against Methicillin-resistant S. aureus (MRSA), were loaded on it to improve their effectiveness. The nanocomposites were characterized using FTIR, XRD, UV-Vis, FE-SEM/EDX, and Zeta potential analyses, followed by an evaluation of their antibacterial activity toward MRSA. Based on the results, drug loaded GO-PEG nanocomposites with loading efficiencies of 81% and 92% for penicillin and oxacillin, respectively, were successfully synthesized. They showed a controlled release within six days. The zeta potential of GO-PEG-oxacillin and penicillin was -13 mV and -11 mV, respectively. The composites showed much more activity against MRSA (80-85% inhibition) in comparison to GO-PEG (almost 0% inhibition) and pure antibiotics (40-45% inhibition). SEM images of MRSA treated with GO-PEG-antibiotics showed a deformation in the structure of bacterial cells, which led to the collapse of their intracellular components. These results demonstrate the effectiveness of utilizing the GO-based nanoplatforms in enhancing the antibacterial activity of the antibiotics.en_US
dc.identifier.citationMohammadi Tabar, M., Khaleghi, M., Bidram, E., Zarepour, A., & Zarrabi, A. (2022). Penicillin and Oxacillin Loaded on PEGylated-Graphene Oxide to Enhance the Activity of the Antibiotics against Methicillin-Resistant Staphylococcus aureus. Pharmaceutics, 14(10), 2049.en_US
dc.identifier.doi10.3390/pharmaceutics14102049en_US
dc.identifier.issn1999-4923en_US
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85140839064en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://dx.doi.org/10.3390/pharmaceutics14102049
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3347
dc.identifier.volume14en_US
dc.identifier.wosWOS:000873365500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarepour, Atefeh
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofPHARMACEUTICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGraphene Oxideen_US
dc.subjectAntibiotic Resistanceen_US
dc.subjectPenicillinen_US
dc.subjectOxacillinen_US
dc.subjectMethicillin-Resistant Staphylococcus Aureusen_US
dc.titlePenicillin and oxacillin loaded on pegylated-graphene oxide to enhance the activity of the antibiotics against methicillin-resistant staphylococcus aureusen_US
dc.typeArticleen_US

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