A case mimicking chronic myeloid leukemia with t(8;22)(p11;q11)/BCR-FGFR1 and sequential transformation to B-acute lymphoblastic leukemia and acute myeloid leukemia

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dc.authoridVeysel Sabri Hançer / 0000-0003-2994-1077en_US
dc.authorscopusidVeysel Sabri Hançer / 6506533543
dc.authorwosidVeysel Sabri Hançer / X-8971-2018
dc.contributor.authorBayrak, Ayşe Gül
dc.contributor.authorUçur, Ali
dc.contributor.authorDağlar-Aday, Aynur
dc.contributor.authorBağatır, Gülçin
dc.contributor.authorErdem, Simge
dc.contributor.authorHançer, Veysel Sabri
dc.contributor.authorNalçacı, Meliha
dc.contributor.authorÖztürk, Şükrü
dc.contributor.authorCefle, Kıvanç
dc.contributor.authorPalandüz, Şükrü
dc.contributor.authorYavuz, Akif Selim
dc.date.accessioned2021-01-19T07:46:19Z
dc.date.available2021-01-19T07:46:19Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractMyeloid/lymphoid neoplasm is a rare malignancy with an aggressive course and rapid transformation to acute myeloid leukemia (AML), or less frequently to acute lymphoblastic leukemia (ALL). Cases with t(8;22)(p11;q11) BCR-FGFR1 fusion gene may be misdiagnosed with chronic myeloid leukemia (CML), due to a very similar morphologic and clinical profile. We report a case of 48-year-old woman who complained of weakness and gastric pain. She had splenomegaly, eosinophilia, and elevated white blood cells. Bone marrow (BM) aspiration biopsy was performed with an initial diagnosis of CML. Cytogenetic analysis of the BM showed a 46,XX,t(8;22)(p11.2;q11.2). She was diagnosed with myeloid/lymphoid neoplasm with eosinophilia and rearrangement of FGFR1 gene. Throughout the chronic phase, the patient was treated with hydroxurea. Additional chromosomal abnormalities developed during therapy. Owing to the (8;22) clone, our patient did not respond to the treatment and rapidly transformed first to B-ALL and then AML. To the best of our knowledge, this is the first MPN patient with rearrangement of BCR and FGFR1 genes with rapid transformation to B-ALL and then to AML.en_US
dc.identifier.citationBayrak, A. G., Ucur, A., Aday, A. D., Bagatır, G., Erdem, S., Hancer, V. S., ... & Yavuz, A. S. A case mimicking chronic myeloid leukemia with t (8; 22)(p11; q11)/BCR-FGFR1 and sequential transformation to B-acute lymphoblastic leukemia and acute myeloid leukemia. Journal of Hematopathology, 1-6.en_US
dc.identifier.doi10.1007/s12308-020-00429-1en_US
dc.identifier.issn1868-9256en_US
dc.identifier.scopus2-s2.0-85099109290en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://www.doi.org/10.1007/s12308-020-00429-1
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1349
dc.identifier.wosWOS:000606311500003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorHançer, Veysel Sabri
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofJournal of Hematopathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFGFR1 Geneen_US
dc.subjectFGFR1/BCR Fusionen_US
dc.subjectLeukemiaen_US
dc.titleA case mimicking chronic myeloid leukemia with t(8;22)(p11;q11)/BCR-FGFR1 and sequential transformation to B-acute lymphoblastic leukemia and acute myeloid leukemiaen_US
dc.typeArticleen_US

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