Transforming growth factor-beta (TGF-?) in prostate cancer: A dual function mediator?

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.contributor.authorMirzaei, S.
dc.contributor.authorPaskeh, M.D.A.
dc.contributor.authorSaghari, Y.
dc.contributor.authorZarrabi, A.
dc.contributor.authorHamblin, M.R.
dc.contributor.authorEntezari, M.
dc.contributor.authorHashemi, M.
dc.contributor.authorAref, A.R.
dc.contributor.authorHushmandi, K.
dc.contributor.authorKumar, A.P.
dc.contributor.authorRabiee, N.
dc.contributor.authorAshrafizadeh, M.
dc.date.accessioned2022-03-10T11:19:30Z
dc.date.available2022-03-10T11:19:30Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractTransforming growth factor-beta (TGF-?) is a member of a family of secreted cytokines with vital biological functions in cells. The abnormal expression of TGF-? signaling is a common finding in pathological conditions, particularly cancer. Prostate cancer (PCa) is one of the leading causes of death among men. Several genetic and epigenetic alterations can result in PCa development, and govern its progression. The present review attempts to shed some light on the role of TGF-? signaling in PCa. TGF-? signaling can either stimulate or inhibit proliferation and viability of PCa cells, depending on the context. The metastasis of PCa cells is increased by TGF-? signaling via induction of EMT and MMPs. Furthermore, TGF-? signaling can induce drug resistance of PCa cells, and can lead to immune evasion via reducing the anti-tumor activity of cytotoxic T cells and stimulating regulatory T cells. Upstream mediators such as microRNAs and lncRNAs, can regulate TGF-? signaling in PCa. Furthermore, some pharmacological compounds such as thymoquinone and valproic acid can suppress TGF-? signaling for PCa therapy. TGF-? over-expression is associated with poor prognosis in PCa patients. Furthermore, TGF-? up-regulation before prostatectomy is associated with recurrence of PCa. Overall, current review discusses role of TGF-? signaling in proliferation, metastasis and therapy response of PCa cells and in order to improve knowledge towards its regulation, upstream mediators of TGF-? such as non-coding RNAs are described. Finally, TGF-? regulation and its clinical application are discussed. © 2022en_US
dc.identifier.citationMirzaei, S., Paskeh, M. D. A., Saghari, Y., Zarrabi, A., Hamblin, M. R., Entezari, M., . . . Samarghandian, S. (2022). Transforming growth factor-beta (TGF-β) in prostate cancer: A dual function mediator? International Journal of Biological Macromolecules, 206, 435-452. doi:10.1016/j.ijbiomac.2022.02.094en_US
dc.identifier.doi10.1016/j.ijbiomac.2022.02.094en_US
dc.identifier.endpage452en_US
dc.identifier.issn0141-8130en_US
dc.identifier.pmid35202639en_US
dc.identifier.scopus2-s2.0-85125524876en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage435en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2022.02.094
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2543
dc.identifier.volume206en_US
dc.identifier.wosWOS:000782126100004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofInternational Journal of Biological Macromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomarkeren_US
dc.subjectChemotherapyen_US
dc.subjectImmunotherapyen_US
dc.subjectNon-Coding RNAen_US
dc.subjectProstate Canceren_US
dc.subjectTGF-βen_US
dc.titleTransforming growth factor-beta (TGF-?) in prostate cancer: A dual function mediator?en_US
dc.typeArticleen_US

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