Anti-Inflammatory, Antioxidant and Neuroprotective Effects of Niacin on Mild Traumatic Brain Injury in Rats

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dc.authoridColakoglu Ozkaya, Seyma/0000-0003-0103-5734
dc.authoridYegen, Berrak/0000-0003-0791-0165
dc.authoridKoyuncuoğlu, Türkan/0000-0003-4749-9470
dc.authorwosidColakoglu Ozkaya, Seyma/ACR-1833-2022
dc.authorwosidYegen, Berrak/O-6652-2017
dc.authorwosidKoyuncuoğlu, Türkan/AAD-3962-2021
dc.contributor.authorOzaydin, Dilan
dc.contributor.authorBektasoglu, Pinar Kuru
dc.contributor.authorKoyuncuoglu, Turkan
dc.contributor.authorOzkaya, Seyma Colakoglu
dc.contributor.authorKoroglu, Ayca Karagoz
dc.contributor.authorAkakin, Dilek
dc.contributor.authorErzik, Can
dc.date.accessioned2024-05-19T14:39:33Z
dc.date.available2024-05-19T14:39:33Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description21st Turkish National Neuroscience Congress -- JUN 08-11, 2021 -- Bolu, TURKEYen_US
dc.description.abstractAIM: To study the effects of niacin, a water-soluble vitamin, on inflammation, oxidative stress and apoptotic processes observed after mild traumatic brain injury (TBI).MATERIAL and METHODS: A total of 25 Wistar albino male rats were randomly divided into control (n=9), TBI + Placebo group (n=9), TBI + niacin (500 mg/kg; n=7) groups. Mild TBI was performed under anesthesia by dropping a 300 g weight from a height of 1 meter onto the skull. Behavioral tests were applied before and 24 hours after TBI. Luminol and lucigenin levels and tissue cytokine levels were measured. Histopathological damage was scored in brain tissue.RESULTS: After mild TBI, luminol and lucigenin levels were increased (p<0.001), and their levels were decreased with niacin treatment (p<0.01-p<0.001). An increased score was obtained with trauma in the tail suspension test (p<0.01), showing depressive behavior. The number of entries to arms in Y-maze test were decreased in TBI group compared to pre-traumatic values (p<0.01), while discrimination (p<0.05) and recognition indices (p<0.05) in object recognition test were decreased with trauma, but niacin treatment did not change the outcomes in behavioral tests. Levels of the anti-inflammatory cytokine IL-10 were decreased with trauma, and increased with niacin treatment (p<0.05). The histological damage score was increased with trauma (p<0.001), and decreased with niacin treatment in the cortex (p<0.05), and hippocampal dentate gyrus region (p<0.01).CONCLUSION: Niacin treatment after mild TBI inhibited trauma-induced production of reactive oxygen derivatives and elevated the anti-inflammatory IL-10 level. Niacin treatment ameliorated the histopathologically evident damage.en_US
dc.identifier.doi10.5137/1019-5149.JTN.42563-22.3
dc.identifier.endpage1037en_US
dc.identifier.issn1019-5149
dc.identifier.issue6en_US
dc.identifier.pmid37309637en_US
dc.identifier.scopus2-s2.0-85175023514en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1028en_US
dc.identifier.urihttps://doi.org10.5137/1019-5149.JTN.42563-22.3
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4804
dc.identifier.volume33en_US
dc.identifier.wosWOS:001115397600026en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectBrain Traumaen_US
dc.subjectNeuroprotectionen_US
dc.subjectNiacinen_US
dc.subjectVitamin B3en_US
dc.titleAnti-Inflammatory, Antioxidant and Neuroprotective Effects of Niacin on Mild Traumatic Brain Injury in Ratsen_US
dc.typeConference Objecten_US

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