Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathways

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dc.authoridCordani, Marco/0000-0001-9342-4862
dc.authorwosidCordani, Marco/ABF-4669-2021
dc.contributor.authorPashootan, Parya
dc.contributor.authorSaadati, Fatemeh
dc.contributor.authorFahimi, Hossein
dc.contributor.authorRahmati, Marveh
dc.contributor.authorStrippoli, Raffaele
dc.contributor.authorZarrabi, Ali
dc.contributor.authorCordani, Marco
dc.date.accessioned2024-05-19T14:39:06Z
dc.date.available2024-05-19T14:39:06Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractPhotodynamic therapy (PDT) represents a non-invasive treatment strategy currently utilized in the clinical management of selected cancers and infections. This technique is predicated on the administration of a photo-sensitizer (PS) and subsequent irradiation with light of specific wavelengths, thereby generating reactive oxygen species (ROS) within targeted cells. The cellular effects of PDT are dependent on both the localization of the PS and the severity of ROS challenge, potentially leading to the stimulation of various cell death modalities. For many years, the concept of regulated cell death (RCD) triggered by photodynamic reactions predominantly encompassed apoptosis, necrosis, and autophagy. However, in recent decades, further explorations have unveiled additional cell death modalities, such as necroptosis, ferroptosis, cuproptosis, pyroptosis, parthanatos, and immunogenic cell death (ICD), which helps to achieve tumor cell elimination. Recently, nanoparticles (NPs) have demonstrated substantial advantages over traditional PSs and become important components of PDT, due to their improved physicochemical properties, such as enhanced solubility and superior specificity for targeted cells. This review aims to summarize recent advancements in the applications of different metal-based NPs as PSs or delivery systems for optimized PDT in cancer treatment. Furthermore, it mechanistically highlights the contribution of RCD pathways during PDT with metal NPs and how these forms of cell death can improve specific PDT regimens in cancer therapy.en_US
dc.description.sponsorshipNational Institute of Genetic Engineering and Biotechnology (NIGEB); Spanish Ministry of Science and Innovation, Agencia Estatal de Investigacion (MCIN/AEI) [980301-I-728]; European UnionNextGeneration (EU/PRTR) [RYC2021-031003-I]; Ministry for Health of Italyen_US
dc.description.sponsorshipM.A.M. appreciates financial support of National Institute of Genetic Engineering and Biotechnology (NIGEB) and the international grant program (No.: 980301-I-728). M.C. is supported with a Ramon y Cajal grant (RYC2021-031003-I) from the Spanish Ministry of Science and Innovation, Agencia Estatal de Investigacion (MCIN/AEI/10.13039/501100011033), and European UnionNextGeneration (EU/PRTR). R.S. was supported by Ministry for Health of Italy (Ricerca Corrente).en_US
dc.identifier.doi10.1016/j.ijpharm.2023.123622
dc.identifier.issn0378-5173
dc.identifier.issn1873-3476
dc.identifier.pmid37989403en_US
dc.identifier.scopus2-s2.0-85178494268en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org10.1016/j.ijpharm.2023.123622
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4701
dc.identifier.volume649en_US
dc.identifier.wosWOS:001128565300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Pharmaceuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectApoptosisen_US
dc.subjectAutophagyen_US
dc.subjectImmunogenic Cell Deathen_US
dc.subjectMetallic Nanoparticlesen_US
dc.subjectPhotodynamic Therapyen_US
dc.subjectRegulated Cell Deathen_US
dc.titleMetal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathwaysen_US
dc.typeReview Articleen_US

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