Apoptosis-inducing, anti-angiogenic and anti-migratory effects of a dinuclear Pd(II) complex on breast cancer: A promising novel compound

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dc.authoridUvez, Ayca/0000-0002-3875-2465
dc.authorwosidUvez, Ayca/AAH-8851-2019
dc.contributor.authorGenel, Merve Erkisa
dc.contributor.authorAdacan, Kaan
dc.contributor.authorSelvi, Selin
dc.contributor.authorKutucu, Deniz Erol
dc.contributor.authorUvez, Ayca
dc.contributor.authorArmutak, Elif Ilkay
dc.contributor.authorSengul, Abdurrahman
dc.date.accessioned2024-05-19T14:39:36Z
dc.date.available2024-05-19T14:39:36Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBecause of the high mortality and morbidity rate of breast cancer, successful management of the disease requires synthesis of novel compounds. To this end, ongoing attempts to create new candidates include synthesis of multinuclear metal complexes. The high DNA binding affinity and cytotoxic activity of these complexes makes them promising as breast cancer treatments. This study investigated anti-growth/cytotoxic effect of the dinuclear Pd(II) complex on breast cancer cell lines (MCF-7, MDA-MB-231) using various methods of staining, flow cytometry, and immunoblotting. The study conducted colony formation, invasion, and migration assays were to assess the effect of the complex on metastasis. Increased caspase-3/7 levels and positive annexin V staining were observed in both cell lines, proving apoptosis. Altered TNFR1 and TRADD expression with caspase-8 cleavage followed by BCL-2 inactivation with loss of mitochondrial membrane potential confirmed the presence of apoptosis in MCF-7 and MDA-MB-231, regardless of p53 expression status. The results implied anti-migration properties. Finally, the study used the CAM assay to assess antiangiogenic properties and showed that the complex inhibited angiogenesis. The study concluded the dinuclear Pd(II) complex warrants further in vivo experiments to show its potential in the treatment of breast cancer.en_US
dc.description.sponsorshipScientific Research Projects Coordina-tion Unit of Istanbul University [31675]en_US
dc.description.sponsorshipThis work was supported by Scientific Research Projects Coordina-tion Unit of Istanbul University [grant number: 31675] .en_US
dc.identifier.doi10.1016/j.mvr.2023.104619
dc.identifier.issn0026-2862
dc.identifier.issn1095-9319
dc.identifier.pmid37898331en_US
dc.identifier.scopus2-s2.0-85175243117en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.1016/j.mvr.2023.104619
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4813
dc.identifier.volume151en_US
dc.identifier.wosWOS:001109381000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofMicrovascular Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectBreast Canceren_US
dc.subjectApoptosisen_US
dc.subjectPalladiumen_US
dc.subjectCam Assayen_US
dc.subjectInvasionen_US
dc.titleApoptosis-inducing, anti-angiogenic and anti-migratory effects of a dinuclear Pd(II) complex on breast cancer: A promising novel compounden_US
dc.typeArticleen_US

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