Graphene- and MXene-based materials for neuroscience: diagnostic and therapeutic applications

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dc.authoridKarasu, Çimen/0000-0002-0954-8465
dc.authoridZarrabi, Ali/0000-0003-0391-1769
dc.authoridIravani, Siavash/0000-0003-3985-7928
dc.authoridNematollahi, Mohammad Hadi/0000-0002-9529-4077
dc.authorwosidKarasu, Çimen/JVZ-4637-2024
dc.authorwosidNematollahi, Hadi/AAD-5922-2019
dc.authorwosidZarrabi, Ali/U-2602-2019
dc.authorwosidIravani, Siavash/F-4046-2014
dc.contributor.authorZarepour, Atefeh
dc.contributor.authorKarasu, Cimen
dc.contributor.authorMir, Yousof
dc.contributor.authorNematollahi, Mohammad Hadi
dc.contributor.authorIravani, Siavash
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2024-05-19T14:50:36Z
dc.date.available2024-05-19T14:50:36Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractMXenes and graphene are two-dimensional materials that have gained increasing attention in neuroscience, particularly in sensing, theranostics, and biomedical engineering. Various composites of graphene and MXenes with fascinating thermal, optical, magnetic, mechanical, and electrical properties have been introduced to develop advanced nanosystems for diagnostic and therapeutic applications, as exemplified in the case of biosensors for neurotransmitter detection. These biosensors display high sensitivity, selectivity, and stability, making them promising tools for neuroscience research. MXenes have been employed to create high-resolution neural interfaces for neuroelectronic devices, develop neuro-receptor-mediated synapse devices, and stimulate the electrophysiological maturation of neural circuits. On the other hand, graphene/derivatives exhibit therapeutic applicability in neuroscience, as exemplified in the case of graphene oxide for targeted delivery of therapeutic agents to the brain. While MXenes and graphene have potential benefits in neuroscience, there are also challenges/limitations associated with their use, such as toxicity, environmental impacts, and limited understanding of their properties. In addition, large-scale production and commercialization as well as optimization of reaction/synthesis conditions and clinical translation studies are very important aspects. Thus, it is important to consider the use of these materials in neuroscience research and conduct further research to obtain an in-depth understanding of their properties and potential applications. By addressing issues related to biocompatibility, long-term stability, targeted delivery, electrical interfaces, scalability, and cost-effectiveness, MXenes and graphene have the potential to greatly advance the field of neuroscience and pave the way for innovative diagnostic and therapeutic approaches for neurological disorders. Herein, recent advances in therapeutic and diagnostic applications of graphene- and MXene-based materials in neuroscience are discussed, focusing on important challenges and future prospects. Therapeutic and diagnostic applications of graphene- and MXene-based materials in neuroscience are deliberated, focusing on important challenges and future prospects.en_US
dc.identifier.doi10.1039/d3bm01114c
dc.identifier.endpage6710en_US
dc.identifier.issn2047-4830
dc.identifier.issn2047-4849
dc.identifier.issue20en_US
dc.identifier.pmid37646462en_US
dc.identifier.scopus2-s2.0-85171163804en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage6687en_US
dc.identifier.urihttps://doi.org10.1039/d3bm01114c
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5758
dc.identifier.volume11en_US
dc.identifier.wosWOS:001062024500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofBiomaterials Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subject2-Dimensional Metal Carbidesen_US
dc.subjectField-Effect Transistoren_US
dc.subjectQuantum Dotsen_US
dc.subjectDrug-Deliveryen_US
dc.subjectIn-Vitroen_US
dc.subjectTi3c2tx Mxeneen_US
dc.subjectPhotothermal Therapyen_US
dc.subjectNano-Grapheneen_US
dc.subjectElectrochemical Detectionen_US
dc.subjectOxide Nanocompositeen_US
dc.titleGraphene- and MXene-based materials for neuroscience: diagnostic and therapeutic applicationsen_US
dc.typeReview Articleen_US

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