Pre-seasonal immunotherapy is effective in both monosensitized and polysensitized patients with allergic rhinitis

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dc.authoridVesile Dilşad Mungan / 0000-0001-8806-2764en_US
dc.authorscopusidVesile Mungan Dilşad / 57902181400
dc.authorwosidVesile Dilşad Mungan / AAQ-4562-2020
dc.contributor.authorSoyyiğit, Şadan
dc.contributor.authorSeçil, Derya
dc.contributor.authorDoğan, Cahit
dc.contributor.authorGökmen, Derya
dc.contributor.authorSin, Betül Ayşe
dc.contributor.authorMısırlıgil, Zeynep
dc.contributor.authorMungan, Vesile Dilşad
dc.contributor.authorAydın, Ömür
dc.date.accessioned2022-05-23T10:10:24Z
dc.date.available2022-05-23T10:10:24Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractBackground. The effectiveness of pre-seasonal allergoid immunotherapy in polysensitized patients are not well-known. The aim of the present study was to compare the clinical efficacy and immunological changes of pre-seasonal allergoid immunotherapy in mono- and polysensitized patients with grass pollen allergy. Methods. Fourty six patients with seasonal allergic rhinitis undergoing pre-seasonal grass pollen immunotherapy and 28 cases followed by conventional drug treatment were included. These groups were divided into monosensitized and polysensitized ones. All patients were followed between March-September with symptom-medication scores, and visual analogue scale (VAS). The quality of life was assessed using the Mini-RQLQ questionnaire. Phleum pratense (Phl p) specific IgE and IgG4 (UNI-CAP 100, Phadia) measurements were performed before and after 7 weeks of immunotherapy. Results. In the immunotherapy group, 15th weekly symptom-medication scores and VAS scores between May and August were found to be significantly lower than those in the control group (p less than 0.05). Phl p specific IgE and IgG4 levels were significantly higher after immunotherapy compared to those before immunotherapy (p = 0.001). Furthermore, Phl p specific IgG4 levels after immunotherapy were also significantly higher than in the control group (p = 0.001). Improvements in activities-practical problems and non-nose/eye symptoms quality of life scores were significantly different between two groups (p less than 0.05). There was no difference in terms of clinical and immunological parameters in mono- and polysensitized patients (p greater than 0.05). Conclusions. This study indicates that clinical improvement with pre-seasonal grass pollen immunotherapy is accompanied by important increase in specific IgG4 blocking antibodies. Furthermore, a single-allergen immunotherapy can lead to similar clinical efficacy and immunological changes in polysensitized as well as monosensitized patients with grass pollen allergy.en_US
dc.identifier.citationSoyyiğit S, Aydın Ö, Seçil D, Doğan C, Gökmen D, Sin BA, Mısırlıgil Z, Mungan VD. Pre-seasonal immunotherapy is effective in both monosensitized and polysensitized patients with allergic rhinitis. Eur Ann Allergy Clin Immunol. 2022 Apr 22. doi: 10.23822/EurAnnACI.1764-1489.252. Epub ahead of print. PMID: 35448936.en_US
dc.identifier.doi10.23822/EurAnnACI.1764-1489.252.en_US
dc.identifier.issn1764-1489en_US
dc.identifier.pmid35448936en_US
dc.identifier.urihttp://doi.org/10.23822/EurAnnACI.1764-1489.252.
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2716
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMungan, Vesile Dilşad
dc.language.isoenen_US
dc.publisherEDRALSWR SpAen_US
dc.relation.ispartofEuropean Annals Allergy and Clinic Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPre-seasonal Immunotherapyen_US
dc.subjectMonosensitizeden_US
dc.subjectPolysensitizeden_US
dc.subjectSpecific IgEen_US
dc.subjectSpecific IgG4en_US
dc.titlePre-seasonal immunotherapy is effective in both monosensitized and polysensitized patients with allergic rhinitisen_US
dc.typeArticleen_US

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