Biomonitoring of heavy metal(oid)s in the residents of abandoned mining district in northern cyprus

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dc.authoridSemra Şardaş / 0000-0001-5456-8636en_US
dc.authorscopusidSemra Şardaş / 7003286974
dc.authorwosidSemra Şardaş / J-2175-2018
dc.contributor.authorKocadal, Kumsal
dc.contributor.authorAlkaş, Fehmi Burak
dc.contributor.authorUlutaş, Onur Kenan
dc.contributor.authorKurt, Mehmet Ali
dc.contributor.authorBattal, Dilek
dc.contributor.authorŞardaş, Semra
dc.contributor.authorEtikan, İlker
dc.contributor.authorSaygı, Sahan
dc.date.accessioned2021-01-08T11:02:15Z
dc.date.available2021-01-08T11:02:15Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractAbstract Several heavy metal(oid)s are known mutagens and/or carcinogens. Exposure to these elements can lead to the development of malignancies. Gemikonagi, which is in the western part of Cyprus, was the hometown of mining operations. It is believed that the mining site is a significant heavy metal(oid) source for the environment and residents. In this biomonitoring study, a total of 60 blood samples from Gemikonagi region (n = 30) and from a control region located 40 km northeast from the mining site, Tepebasi (n = 30), and 5 soil samples from each region were collected to conduct heavy metal analysis using ICP-MS. To conduct genotoxicity analysis, alkaline comet assay and in vivo micronucleus assays were used. t test for independent samples and Mann-Whitney U tests were applied. Copper and iron were found to be enriched in Gemikonagi, while arsenic was found to be enriched in Tepebasi. Genotoxicity analyses demonstrated a statistically significant increase in parameters of micronuclei frequency (p value = 0.0001) and Comet Assay statistics upon exposure to some elements, such as arsenic (p value = 0.04) and copper (p value = 0.012). The results indicate that a general enrichment in heavy elements is not endemic to Gemikonagi, but a problem that might be generalized to the entirety of Cyprus.en_US
dc.identifier.citationKocadal, K., Alkas, F.B., Ulutas, O.K. et al. Biomonitoring of Heavy Metal(oid)s in the Residents of Abandoned Mining District in Northern Cyprus. Biol Trace Elem Res (2021). https://doi.org/10.1007/s12011-020-02520-1en_US
dc.identifier.doi10.1007/s12011-020-02520-1en_US
dc.identifier.issn1559-0720en_US
dc.identifier.issn0163-4984en_US
dc.identifier.pmid33409917en_US
dc.identifier.scopus2-s2.0-85099036849en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-020-02520-1
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1306
dc.identifier.wosWOS:000605536800002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞardaş, Semra
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomonitoringen_US
dc.subjectHeavy Metalsen_US
dc.subjectEnvironmental Toxicologyen_US
dc.subjectAlkaline Comet Assayen_US
dc.subjectIn Vivo Micronucleus Assayen_US
dc.subjectCyprusen_US
dc.titleBiomonitoring of heavy metal(oid)s in the residents of abandoned mining district in northern cyprusen_US
dc.typeArticleen_US

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