Serum adipokine levels in patients with sarcoidosis

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dc.authoridŞenol Kobak / 0000-0001-8270-640X
dc.authorscopusidŞenol Kobak / 12782228700
dc.authorwosidŞenol Kobak / AAO-2482-2020
dc.contributor.authorKobak, Şenol
dc.contributor.authorSemiz, Hüseyin
dc.contributor.authorAkyıldız, Mühittin
dc.contributor.authorGökduman, Ayşe
dc.contributor.authorAtabay, Tennur
dc.contributor.authorVural, Hüseyin
dc.date.accessioned2020-08-30T20:06:16Z
dc.date.available2020-08-30T20:06:16Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionKobak, Şenol (isu author)
dc.description.abstractBackground Sarcoidosis is a chronic inflammatory disease characterized by non-caseating granuloma which etiology is unknown yet. Adipokines are different proteins synthesized by adipose tissue that have an influence on angiogenesis, hemostasis, lipid metabolism, and immune system regulation. Adipokines may play a role in the pathogenesis of sarcoidosis. Objectives To evaluate the serum adipokine levels in patients with sarcoidosis and to determine a possible correlation with clinical and laboratory signs of disease. Methods Forty-four biopsy-proven sarcoidosis patients followed at a single center and age- and sex-matched 41 healthy volunteers were included in the study. Demographic, clinical, laboratory, and radiological data were recorded and body mass index (BMI) was calculated in all patients. Routine laboratory tests (blood glucose, liver, and kidney function test) were measured. Serum adiponectin and leptin levels were measured by ELISA method. Results Among 44sarcoidosis patients, 13 (29.5%) were male and 31 (70.5%) were female. Twenty-one (47.7%) patients had erythema nodosum, three (6.8%) had uveitis, 40 (90.9%) had arthralgia, 32 (72.7%) had arthritis, 15 (34.1%) had enthesitis. Laboratory evaluation showed increased serum ACE level in 24 (54.5%) patients, increased serum calcium level in 11 (25%) patients, increased serum D3 level in 5 (11.4%) patients, and increased ESR and CRP levels in 22 (50%) and 23 (52.3%) patients, respectively. Compared with the control group, serum adiponectin levels were significantly higher in patients with sarcoidosis(p = 0.007). Serum adiponectin level was associated with arthralgia and ankle joint swelling (p = 0.007, p = 0.006 respectively). Serum leptin levels were similar in sarcoidosis patients and controls (p = 0.327). There was no relationship between serum leptin level and disease features (p > 0.05). Conclusions In this study, high serum adiponectin level was detected in patients with sarcoidosis while serum leptin level was similar in the sarcoidosis and control group. Adiponectin, an anti-inflammatory protein, may play a role in the pathogenesis of sarcoidosis. Studies are needed to shed light on this topic.en_US
dc.identifier.citationKobak, S., Semiz, H., Akyildiz, M., Gokduman, A., Atabay, T., & Vural, H. (2020). Serum adipokine levels in patients with sarcoidosis. CLINICAL RHEUMATOLOGY, 39(7), 2121–2125. https://doi.org/10.1007/s10067-020-04980-1en_US
dc.identifier.doi10.1007/s10067-020-04980-1en_US
dc.identifier.endpage2125en_US
dc.identifier.issn0770-3198en_US
dc.identifier.issn1434-9949en_US
dc.identifier.issue7en_US
dc.identifier.pmid32060810en_US
dc.identifier.scopus2-s2.0-85079445991en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2121en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-020-04980-1
dc.identifier.urihttps://hdl.handle.net/20.500.12713/447
dc.identifier.volume39en_US
dc.identifier.wosWOS:000516130100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKobak, Şenolen_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdipokinesen_US
dc.subjectAssociationen_US
dc.subjectLeptinen_US
dc.subjectSarcoidosisen_US
dc.titleSerum adipokine levels in patients with sarcoidosisen_US
dc.typeArticleen_US

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