Effects of epoxygenases on the nonadrenergic noncholinergic relaxant responses induced by electrical field stimulation in rabbit corpus cavernosum

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dc.authoridYusuf Sarıoğlu / 0000-0002-9227-365Xen_US
dc.authorscopusidYusuf Sarıoğlu / 7003713314
dc.authorwosidYusuf Sarıoğlu / DRN-8389-2022
dc.contributor.authorIsli, Fatma
dc.contributor.authorYildirim, Seniz
dc.contributor.authorFincan, Gokce Sevim Ozturk
dc.contributor.authorErcan, Sevim
dc.contributor.authorSarıoğlu, Yusuf
dc.date.accessioned2020-08-30T20:06:38Z
dc.date.available2020-08-30T20:06:38Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractWe aimed to investigate the effects of epoxygenases on electrical field stimulation (EFS)-mediated nitric oxide (NO)-dependent and NO-independent nonadrenergic noncholinergic (NANC) relaxations in isolated rabbit corpus cavernosum. The tissues of 20 male adult albino rabbits (2.5-3 kg) were suspended in organ baths containing aerated Krebs solution, and isometric contractions were recorded. EFS-mediated NANC relaxations were obtained on phenylephrin (3 x 10(-5) M)-contracted tissues in the presence of guanethidine (10(-6) M) and atropine (10(-6) M). Miconazole (10(-9)-10(-4) M), 17-octadecynoic acid (ODYA) (10(-10)-10(-5) M), 14,15-epoxyeicosatrienoic acid (EET) (10(-11)-10(-8) M), 11,12-EET (10(-12)-3 x 10(-8) M) and 20-hydroxyeicosatetraenoic acid (HETE) (10(-11)-3 x 10(-8) M) were added cumulatively (n = 5-7 for each set of experiments). For NO-independent relaxations, N-omega-nitro-l-arginine methyl ester (l-NAME) (10(-4) M) was added before a group of experiments. Depending on the concentration, miconazole, 17-ODYA, 14,15-EET, 11,12-EET, and 20-HETE significantly enhanced both NO-dependent and NO-independent EFS-mediated relaxations (p < 0.05). Epoxygenases showed similar effect on NO-dependent and NO-independent relaxant responses except 20-HETE which caused significantly more enhanced relaxation on NO-dependent responses (p < 0.05). No drug caused a significant relaxation response on tissues contracted with phenylephrine. Epoxygenases contribute to EFS-mediated NO-dependent and NO-independent NANC relaxations by presynaptic mechanisms, offering a new treatment alternative for erectile dysfunction which needs to be explored in further in vivo, molecular and clinical studies.en_US
dc.description.sponsorshipGazi University Research FoundationGazi University [01/2011-98]en_US
dc.identifier.citationIsli, F., Yildirim, S., Ozturk Fincan, G. S., Ercan, S., & Sarioglu, Y. (2019). Effects of epoxygenases on the nonadrenergic noncholinergic relaxant responses induced by electrical field stimulation in rabbit corpus cavernosum. Andrologia, 51(8), e13317.en_US
dc.identifier.doi10.1111/and.13317en_US
dc.identifier.issn0303-4569en_US
dc.identifier.issn1439-0272en_US
dc.identifier.issue8en_US
dc.identifier.pmid31107569en_US
dc.identifier.scopus2-s2.0-85066105555en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.13317
dc.identifier.urihttps://hdl.handle.net/20.500.12713/580
dc.identifier.volume51en_US
dc.identifier.wosWOS:000478102200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSarıoğlu, Yusufen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCorpus Cavernosumen_US
dc.subjectElectrical Field Stimulationen_US
dc.subjectEpoxygenaseen_US
dc.subjectIsolated Organ Bathen_US
dc.subjectNonadrenergic Noncholinergic Systemen_US
dc.titleEffects of epoxygenases on the nonadrenergic noncholinergic relaxant responses induced by electrical field stimulation in rabbit corpus cavernosumen_US
dc.typeArticleen_US

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