The long and short non-coding RNAs modulating EZH2 signaling in cancer

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorMirzaei, Sepideh
dc.contributor.authorGholami, Mohammad Hossein
dc.contributor.authorHushmandi, Kiavash
dc.contributor.authorHshemi, Farid
dc.contributor.authorZabolian, Amirhossein
dc.contributor.authorCanadas, Israel
dc.contributor.authorZarrabi, Ali
dc.contributor.authorNabavi, Noushin
dc.contributor.authorAref, Amir Reza
dc.contributor.authorCrea, Francesco
dc.contributor.authorWang, Yuzhuo
dc.contributor.authorAshrafizadeh, Milad
dc.contributor.authorKumar, Alan Prem
dc.date.accessioned2022-03-14T06:23:30Z
dc.date.available2022-03-14T06:23:30Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractNon-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in encoding proteins. However, they participate in developmental and biological processes and their abnormal expression affects cancer progression. These RNA molecules can function as upstream mediators of different signaling pathways and enhancer of zeste homolog 2 (EZH2) is among them. Briefly, EZH2 belongs to PRCs family and can exert functional roles in cells due to its methyltransferase activity. EZH2 affects gene expression via inducing H3K27me3. In the present review, our aim is to provide a mechanistic discussion of ncRNAs role in regulating EZH2 expression in different cancers. MiRNAs can dually induce/inhibit EZH2 in cancer cells to affect downstream targets such as Wnt, STAT3 and EMT. Furthermore, miRNAs can regulate therapy response of cancer cells via affecting EZH2 signaling. It is noteworthy that EZH2 can reduce miRNA expression by binding to promoter and exerting its methyltransferase activity. Small-interfering RNA (siRNA) and short-hairpin RNA (shRNA) are synthetic, short ncRNAs capable of reducing EZH2 expression and suppressing cancer progression. LncRNAs mainly regulate EZH2 expression via targeting miRNAs. Furthermore, lncRNAs induce EZH2 by modulating miRNA expression. Circular RNAs (CircRNAs), like lncRNAs, affect EZH2 expression via targeting miRNAs. These areas are discussed in the present review with a focus on molecular pathways leading to clinical translation.en_US
dc.identifier.citationMirzaei S, Gholami MH, Hushmandi K, Hshemi F, Zabolian A, Canadas I, Zarrabi A, Nabavi N, Aref AR, Crea F, Wang Y, Ashrafizadeh M, Kumar AP. The long and short non-coding RNAs modulating EZH2 signaling in cancer. J Hematol Oncol. 2022 Mar 2;15(1):18.en_US
dc.identifier.doi10.1186/s13045-022-01235-1en_US
dc.identifier.issue8en_US
dc.identifier.pmid35236381en_US
dc.identifier.scopus2-s2.0-85125611290en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1186/s13045-022-01235-1
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2548
dc.identifier.volume15(1)en_US
dc.identifier.wosWOS:000763414900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isotren_US
dc.relation.ispartofJ Hematol Oncolen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCancer Therapyen_US
dc.subjectCircRNAen_US
dc.subjectEZH2en_US
dc.subjectLncRNAen_US
dc.subjectMiRNAen_US
dc.subjectShRNAen_US
dc.subjectSiRNAen_US
dc.titleThe long and short non-coding RNAs modulating EZH2 signaling in canceren_US
dc.typeArticleen_US

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