NF-?B as a regulator of cancer metastasis and therapy response: A focus on epithelial-mesenchymal transition

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.contributor.authorMirzaei , Sepideh
dc.contributor.authorSaghari, Sam
dc.contributor.authorBassiri, Farzaneh
dc.contributor.authorRaesi, Rasoul
dc.contributor.authorZarrabi, Ali
dc.contributor.authorHushmandi, Kiavash
dc.contributor.authorSethi, Gautam
dc.contributor.authorTergaonkar, Vinay
dc.date.accessioned2022-05-31T14:16:42Z
dc.date.available2022-05-31T14:16:42Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractMetastasis of tumor cells is a complex challenge and significantly diminishes theoverall survival and prognosis of cancer patients. The epithelial?to?mesenchymaltransition (EMT) is a well?known mechanism responsible for the invasiveness oftumor cells. A number of molecular pathways can regulate the EMT mechanism incancer cells and nuclear factor?kappaB (NF??B) is one of them. The nucleartranslocation of NF??B p65 can induce the transcription of several genes involved inEMT induction. The present review describes NF??B and EMT interaction in cancercells and their association in cancer progression. Due to the oncogenic role NF??Bsignaling, its activation enhances metastasis of tumor cells via EMT induction. Thishas been confirmed in various cancers including brain, breast, lung and gastriccancers, among others. The ZEB1/2, transforming growth factor??, and Slug asinducers of EMT undergo upregulation by NF??B to promote metastasis of tumorcells. After EMT induction driven by NF??B, a significant decrease occurs inE?cadherin levels, while N?cadherin and vimentin levels undergo an increase. Thenoncoding RNAs can potentially also function as upstream mediators and modulateNF??B/EMT axis in cancers. Moreover, NF??B/EMT axis is involved in mediatingJ Cell Physiol. 2022;1–26.wileyonlinelibrary.com/journal/jcp© 2022 Wiley Periodicals LLC.|1Abbreviations:AREG, amphiregulin; circRNA, circular RNA; DLC?1, deleted in liver cancer?1; EMT, epithelial?to?mesenchymal transition; EMT?TFs, EMT?inducing transcription factors;FABP5, fatty acid?binding protein 5; GH, growth hormone; IGF1R, insulin like growth factor?1 receptor; IKK, I?B kinase; IL, interleukin; lncRNA, long noncoding RNA; MANF, mesencephalicastrocyte?derived neutrophic factor; miRNA, microRNA; NF??B, nuclear factor?kappaB; NIK, NF??B inducing kinase; SIRTs, sirtuins; SMC4, structural maintenance of chromosome 4;STAT3, signal transducer and activator of transcription 3; TGF??, transforming growth factor??; TLR?4, toll like growth factor?4; TNF, tumor necrosis factor. drug resistance in tumor cells. Thus, suppressing NF??B/EMT axis can also promotethe sensitivity of cancer cells to chemotherapeutic agentsen_US
dc.identifier.citationMirzaei S, Saghari S, Bassiri F, Raesi R, Zarrabi A, Hushmandi K, Sethi G, Tergaonkar V. NF-κB as a regulator of cancer metastasis and therapy response: A focus on epithelial-mesenchymal transition. J Cell Physiol. 2022 May 13. doi: 10.1002/jcp.30759. Epub ahead of print. PMID: 35561232en_US
dc.identifier.doi10.1002/jcp.30759en_US
dc.identifier.pmid35561232en_US
dc.identifier.scopus2-s2.0-85129783478en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttp://doi.org/10.1002/jcp.30759
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2770
dc.identifier.wosWOS:000794919900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Cellular physicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCancer Therapyen_US
dc.subjectChemoresistanceen_US
dc.subjectEMTen_US
dc.subjectMetastasisen_US
dc.subjectNF‐κBen_US
dc.subjectSignalingen_US
dc.titleNF-?B as a regulator of cancer metastasis and therapy response: A focus on epithelial-mesenchymal transitionen_US
dc.typeArticleen_US

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