Hybrid stromal vascular fraction (hybrid-SVF): a new paradigm in mechanical regenerative cell processing

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dc.authoridPolen Koçak / 0000-0003-4493-1061en_US
dc.authorscopusidPolen Koçak / 57191971267en_US
dc.authorwosidPolen Koçak / CZL-2450-2022en_US
dc.authorwosidPolen Koçak / JHP-3402-2023
dc.contributor.authorTiryaki, Tunc
dc.contributor.authorCohen, Steven Roy
dc.contributor.authorTürkay, Serli Canikyan
dc.contributor.authorKoçak, Polen
dc.contributor.authorSterodimas, Aris
dc.contributor.authorSchlaudraff, Kai-Uwe
dc.contributor.authorDemir, Isil Akguen
dc.contributor.authorAgovino, Annarita
dc.contributor.authorKul, Yaren
dc.date.accessioned2023-08-31T12:09:35Z
dc.date.available2023-08-31T12:09:35Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractBackground:Enzymatic digestion of extracellular matrix (ECM) from lipoaspirate is the conventional form of harvesting stromal vascular fraction (SVF) called enzymatically digested SVF (E-SVF). Mechanical SVF (M-SVF) isolation has emerged as an alternative method, but it has also some limitations in terms of lower cell viability and diminished cell counts. To enhance the SVF qualitatively and quantitatively, we propose a novel concept called hybrid-SVF, in which we combine M-SVF with the concentrated parts of adipose tissue after centrifugation, which is called stromal vascular matrix (SVM). Methods:Hybrid-SVF injection was applied as an adjunctive therapy to fat grafting in 88 patients and 11 samples were evaluated in the laboratory for cell count, viability and cell activity. Results:Experimental results determined that SVM part showed higher cellular activity. SVM and M-SVF showed higher cellular potency than E-SVF. Clinically, none of the patients required an additional session for fat grafting since there was no significant graft resorption. However, seven patients asked for further volume augmentation due to their individual preferences. No major complication was encountered. Conclusions:The usage of hybrid-SVF has a very high regenerative potential due to the ECM support and exceptionally high cell yield in addition to preserved cell potency. Although there are ongoing studies focusing on optimizing cell counts and further clinical applications, we believe that our preliminary results might create a paradigm shift in the area of regenerative fat grafting.en_US
dc.identifier.citationTiryaki, T., Cohen, S. R., Turkay, S. C., Kocak, P., Sterodimas, A., Schlaudraff, K. U., ... & Kul, Y. (2022). Hybrid Stromal Vascular Fraction (Hybrid-SVF): A New Paradigm in Mechanical Regenerative Cell Processing. Plastic and Reconstructive Surgery–Global Open, 10(12), e4702.en_US
dc.identifier.doi10.1097/GOX.0000000000004702en_US
dc.identifier.issn2169-7574en_US
dc.identifier.issue12en_US
dc.identifier.pmid36601591en_US
dc.identifier.scopus2-s2.0-85147759892en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttp://dx.doi.org/10.1097/GOX.0000000000004702
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3965
dc.identifier.volume10en_US
dc.identifier.wosWOS:000905586200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKoçak, Polen
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofPlastic and Reconstructive Surgery-Global Openen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleHybrid stromal vascular fraction (hybrid-SVF): a new paradigm in mechanical regenerative cell processingen_US
dc.typeArticleen_US

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