Spotlights on some electrocardiographic paradigms: how should we evaluate normal reference values of Tp-Te interval, Tp-Te dispersion and Tp-Te/QT ratio?

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dc.authoridSuat Demirkıran / 0000-0002-6769-8875
dc.authoridHidayet Kayançiçek / 0000-0001-6493-5591
dc.authorscopusidSuat Demirkıran / 57219335918
dc.authorscopusidHidayet Kayançiçek / 15837302900
dc.authorwosidSuat Demirkıran / CNR-7390-2022
dc.authorwosidHidayet Kayançiçek / DUY-5949-2022
dc.contributor.authorYılmaz, Mücahid
dc.contributor.authorKayançiçek, Hidayet
dc.contributor.authorGözel, Nevzat
dc.contributor.authorBilen, Mehmet Nail
dc.contributor.authorKurtoğlu, Ertuğrul
dc.contributor.authorSeçen, Özlem
dc.contributor.authorÖner, Pınar
dc.contributor.authorDemirkıran, Suat
dc.contributor.authorUku, Ökkeş
dc.contributor.authorÇekici, Yusuf
dc.contributor.authorEroğlu, Orkun
dc.contributor.authorKeleş, Fikret
dc.date.accessioned2020-09-28T09:02:44Z
dc.date.available2020-09-28T09:02:44Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackground: Experimental and clinical studies evaluating the Tp-Te interval and Tp-Te/QT ratio have reported conflicting data. The overlap between normal Tp-Te/QT ratios (0.17 ±0.02-0.27 ±0.06 ms) and pathological values (0.20 ±0.03-0.30 ±0.06 ms) measured in earlier studies has raised questions about this ECG measurement technique. Objectives: To analyze normal values of the Tp-Te interval, Tp-Te dispersion Tp-Te(d) and the Tp-Te/QT ratio based on electrocardiographic (ECG) assessment across sex and age groups in a healthy Turkish population. Material and methods: A total of 1,485 healthy participants (723 men) were enrolled into the study. The age of the participants ranged 17-75 years and they did not have either any cardiovascular/systemic disorders or risk factors for atherosclerosis which were detected with physical examination and laboratory tests. The Tp-Te interval, Tp-Te(d) and Tp-Te/QT ratio were determined from V1-V6 derivations. Results: For the entire study, the median Tp-Te interval was 66.0 (64.0-70.0) ms, the Tp-Te(d) was 15.0 (10.0-20.0) ms, and the Tp-Te/QT ratio was 0.18 (0.17-0.19). The Pearson's correlation test demonstrated that the Tp-Te/QT ratio significantly correlated with older age (r = 0.297; p < 0.0001), left ventricular (LV) end-diastolic diameter (LVEDD; r = 0.481; p < 0.0001), body mass index (BMI; r = 0.421; p < 0.0001), body surface area (BSA; r = 0.191; p < 0.0001), LV end-diastolic volume (LVEDV; r = 0.484; p < 0.0001), LVEDV index (r = 0.450; p < 0.0001), LV mass (r = 0.548; p < 0.0001), and LV mass index (r = 0.539; p < 0.0001). Conclusions: The reference values for Tp-Te interval, Tp-Te(d) and Tp-Te/QT ratio are associated with age, BMI, BSA, LVEDV, LVEDV index, LV mass, and LV mass index. These structural elements should be considered when using these ECG parameters for assessing repolarization inhomogeneity. These findings may guide further studies assessing healthy and diseased populations.en_US
dc.identifier.citationYılmaz, M., Kayançiçek, H., Gözel, N., Bilen, M. N., Kurtoğlu, E., Seçen, Ö., ... & Eroglu, O. Spotlights on some electrocardiographic paradigms: How should we evaluate normal reference values of Tp-Te interval, Tp-Te dispersion and Tp-Te/QT ratio?. Advances in clinical and experimental medicine: official organ Wroclaw Medical University.en_US
dc.identifier.doi10.17219/acem/117684en_US
dc.identifier.issn1899-5276en_US
dc.identifier.issue9en_US
dc.identifier.pmid32937041en_US
dc.identifier.scopus2-s2.0-85092318081en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.17219/acem/117684
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1121
dc.identifier.volume29en_US
dc.identifier.wosWOS:000577257100009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKayançiçek, Hidayet
dc.institutionauthorDemirkıran, Suat
dc.language.isoenen_US
dc.relation.ispartofAdv Clin Exp Meden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLV Massen_US
dc.subjectLV Mass Indexen_US
dc.subjectTp–Te Dispersionen_US
dc.subjectTp–Te Intervalen_US
dc.subjectTp–Te/QT Ratioen_US
dc.titleSpotlights on some electrocardiographic paradigms: how should we evaluate normal reference values of Tp-Te interval, Tp-Te dispersion and Tp-Te/QT ratio?en_US
dc.typeArticleen_US

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