Biotin-functionalized nanoparticles: an overview of recent trends in cancer detection
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Royal soc chemistry
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Electrochemical bio-sensing is a potent and efficient method for converting various biological recognition events into voltage, current, and impedance electrical signals. Biochemical sensors are now a common part of medical applications, such as detecting blood glucose levels, detecting food pathogens, and detecting specific cancers. As an exciting feature, bio-affinity couples, such as proteins with aptamers, ligands, paired nucleotides, and antibodies with antigens, are commonly used as bio-sensitive elements in electrochemical biosensors. Biotin-avidin interactions have been utilized for various purposes in recent years, such as targeting drugs, diagnosing clinically, labeling immunologically, biotechnology, biomedical engineering, and separating or purifying biomolecular compounds. The interaction between biotin and avidin is widely regarded as one of the most robust and reliable noncovalent interactions due to its high bi-affinity and ability to remain selective and accurate under various reaction conditions and bio-molecular attachments. More recently, there have been numerous attempts to develop electrochemical sensors to sense circulating cancer cells and the measurement of intracellular levels of protein thiols, formaldehyde, vitamin-targeted polymers, huwentoxin-I, anti-human antibodies, and a variety of tumor markers (including alpha-fetoprotein, epidermal growth factor receptor, prostate-specific Ag, carcinoembryonic Ag, cancer antigen 125, cancer antigen 15-3, etc.). Still, the non-specific binding of biotin to endogenous biotin-binding proteins present in biological samples can result in false-positive signals and hinder the accurate detection of cancer biomarkers. This review summarizes various categories of biotin-functional nanoparticles designed to detect such biomarkers and highlights some challenges in using them as diagnostic tools.
Biotin-functionalized nanoparticles enhance cancer detection by targeting biotin receptors, which are overexpressed on cancer cells. This targeted approach improves imaging accuracy and efficacy in identifying cancerous tissues.
Açıklama
Anahtar Kelimeler
Cell Lung-Cancer, Targeting Drug-Delivery, Circulating Tumor-Cells, Alpha-Fetoprotein, Quantum Dots, Signal Amplifcation, Gold Nanoparticles, Rational Design, Human Serum, Avidin
Kaynak
Nanoscale
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
16
Sayı
27
Künye
Fathi-Karkan, S., Sargazi, S., Shojaei, S., Far, B. F., Mirinejad, S., Cordani, M., ... & Ghavami, S. (2024). Biotin-functionalized nanoparticles: An overview of recent trends in cancer detection. Nanoscale.
