Biotin-functionalized nanoparticles: an overview of recent trends in cancer detection

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dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorFathi-karkan, Sonia
dc.contributor.authorSargazi, Saman
dc.contributor.authorShojaei, Shirin
dc.contributor.authorFarasati Far, Bahareh
dc.contributor.authorMirinejad, Shekoufeh
dc.contributor.authorCordani, Marco
dc.contributor.authorKhosravi, Arezoo
dc.contributor.authorZarrabi, Ali
dc.contributor.authorGhavami, Saeid
dc.date.accessioned2025-04-18T10:17:43Z
dc.date.available2025-04-18T10:17:43Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractElectrochemical bio-sensing is a potent and efficient method for converting various biological recognition events into voltage, current, and impedance electrical signals. Biochemical sensors are now a common part of medical applications, such as detecting blood glucose levels, detecting food pathogens, and detecting specific cancers. As an exciting feature, bio-affinity couples, such as proteins with aptamers, ligands, paired nucleotides, and antibodies with antigens, are commonly used as bio-sensitive elements in electrochemical biosensors. Biotin-avidin interactions have been utilized for various purposes in recent years, such as targeting drugs, diagnosing clinically, labeling immunologically, biotechnology, biomedical engineering, and separating or purifying biomolecular compounds. The interaction between biotin and avidin is widely regarded as one of the most robust and reliable noncovalent interactions due to its high bi-affinity and ability to remain selective and accurate under various reaction conditions and bio-molecular attachments. More recently, there have been numerous attempts to develop electrochemical sensors to sense circulating cancer cells and the measurement of intracellular levels of protein thiols, formaldehyde, vitamin-targeted polymers, huwentoxin-I, anti-human antibodies, and a variety of tumor markers (including alpha-fetoprotein, epidermal growth factor receptor, prostate-specific Ag, carcinoembryonic Ag, cancer antigen 125, cancer antigen 15-3, etc.). Still, the non-specific binding of biotin to endogenous biotin-binding proteins present in biological samples can result in false-positive signals and hinder the accurate detection of cancer biomarkers. This review summarizes various categories of biotin-functional nanoparticles designed to detect such biomarkers and highlights some challenges in using them as diagnostic tools. Biotin-functionalized nanoparticles enhance cancer detection by targeting biotin receptors, which are overexpressed on cancer cells. This targeted approach improves imaging accuracy and efficacy in identifying cancerous tissues.
dc.description.sponsorshipAgencia Estatal de Investigacin
dc.identifier.citationFathi-Karkan, S., Sargazi, S., Shojaei, S., Far, B. F., Mirinejad, S., Cordani, M., ... & Ghavami, S. (2024). Biotin-functionalized nanoparticles: An overview of recent trends in cancer detection. Nanoscale.
dc.identifier.doi10.1039/d4nr00634h
dc.identifier.endpage12792
dc.identifier.issn2040-3364
dc.identifier.issn2040-3372
dc.identifier.issue27
dc.identifier.scopus2-s2.0-85196732724
dc.identifier.scopusqualityQ1
dc.identifier.startpage12750
dc.identifier.urihttp://dx.doi.org/10.1039/d4nr00634h
dc.identifier.urihttps://hdl.handle.net/20.500.12713/7012
dc.identifier.volume16
dc.identifier.wosWOS:001250443900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorZarrabi, Ali
dc.institutionauthoridAli Zarrabi / 0000-0003-0391-1769
dc.language.isoen
dc.publisherRoyal soc chemistry
dc.relation.ispartofNanoscale
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCell Lung-Cancer
dc.subjectTargeting Drug-Delivery
dc.subjectCirculating Tumor-Cells
dc.subjectAlpha-Fetoprotein
dc.subjectQuantum Dots
dc.subjectSignal Amplifcation
dc.subjectGold Nanoparticles
dc.subjectRational Design
dc.subjectHuman Serum
dc.subjectAvidin
dc.titleBiotin-functionalized nanoparticles: an overview of recent trends in cancer detection
dc.typeOther

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