Gastrointestinal Bleeding Risk Factors in Patients with Type 2 Diabetes Mellitus

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dc.authoridSavaş Volkan Kişioǧlu / 0000-0002-7742-048X
dc.authorscopusidSavaş Volkan Kişioǧlu / 57216558997
dc.authorwosidSavaş Volkan Kişioǧlu / AAT-3031-2021
dc.contributor.authorKişio?lu, Savaş Volkan
dc.contributor.authorHabiboğlu, I.
dc.contributor.authorGünay, Y.E.
dc.contributor.authorDurak, S.
dc.contributor.authorKaraküllükçü, S.
dc.date.accessioned2022-01-19T13:03:34Z
dc.date.available2022-01-19T13:03:34Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To investigate the factors leading to the development of gastrointestinal bleeding (GIB) by comparing patients with diabetes mellitus Type 2 (T2DM) with dyspeptic complaints without GIB; and patients with T2DM who had GIB, regardless of the presence of helicobacter pylori. Study Design: Analytical study. Place and Duration of Study: Department of Endocrinology and Gastroenterology, Faculty of Medicine, Karadeniz Technical University, from January 2018 to June 2019. Methodology: The patients were divided into GIB and dyspepsia groups. After the identification of patients in both groups, demographic characteristics, drugs, comorbidities, presence of diabetic macro- and micro-vascular complications, and endoscopic findings were examined retrospectively for each patient. Results: There were 106 patients, with 53 patients in each group. Mean age was significantly higher in the GIB group compared to the dyspepsia group (p<0.001). Body mass index (BMI) was significantly lower in the GIB group (p<0.001). Frequency of congestive heart failure (CHF), chronic kidney disease (CKD), and cerebrovascular disease (CVD), heart valve disease, and cardiac arrhythmia was significantly higher in GIB group (p <0.05 for all). No significant correlation was found between acetylsalicylic acid (ASA) use and GIB (p=0.103). The use of nonsteroidal anti-inflammatory drugs (NSAID), novel oral anticoagulants (NOAC), and clopidogrel was significantly higher in the GIB group (p=0.032, p=0.031, and p=0.032, respectively). Proton pump inhibitor (PPI) use was significantly higher in the dyspepsia group (p=0.002). Conclusion: Age, and poly medications were associated with increased frequency of GIB. The use of ASA, when not administered with other agents that may induce GIB, does not increase the risk of developing GIB in obese T2DM patients younger than 65 years of age, who have increased HbA1c levels. © 2022 College of Physicians and Surgeons Pakistan. All rights reserved.en_US
dc.identifier.citationKisioglu, S. V., Habiboglu, I., Gunay, Y. E., Durak, S., Karakullukcu, S., & Fidan, S. (2022). Gastrointestinal bleeding risk factors in patients with type 2 diabetes mellitus. Journal of the College of Physicians and Surgeons Pakistan, 32(1)en_US
dc.identifier.doi10.29271/jcpsp.2022.01.15en_US
dc.identifier.endpage19en_US
dc.identifier.issn1022-386Xen_US
dc.identifier.issue1en_US
dc.identifier.pmid34983141en_US
dc.identifier.scopus2-s2.0-85122031050en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage15en_US
dc.identifier.urihttps://10.29271/jcpsp.2022.01.15
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2407
dc.identifier.volume32en_US
dc.identifier.wosWOS:000762624900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKişioǧlu, Savaş Volkan
dc.language.isoenen_US
dc.publisherCollege of Physicians and Surgeons Pakistanen_US
dc.relation.ispartofJournal of the College of Physicians and Surgeons Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetylsalicylic Aciden_US
dc.subjectDyspepsiaen_US
dc.subjectGastrointestinal Bleedingen_US
dc.subjectMedicationen_US
dc.subjectObesityen_US
dc.subjectRisk factorsen_US
dc.titleGastrointestinal Bleeding Risk Factors in Patients with Type 2 Diabetes Mellitusen_US
dc.typeArticleen_US

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