Amantadine’s Neuroprotective Effects in Rabbit Spinal Cord Ischemia/Reperfusion Model

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dc.authorscopusidBora Gürer / 36448801100
dc.authorwosidBora Gürer / K-1177-2012
dc.contributor.authorÜnlüler, Caner
dc.contributor.authorKuru Bektaşoğlu, Pınar
dc.contributor.authorErgüder, Berrin İmge
dc.contributor.authorArıok, Ata Türker
dc.contributor.authorErmutlu, İlçim
dc.contributor.authorGürer, Bora
dc.contributor.authorKertmen, Hayri
dc.date.accessioned2025-06-04T13:40:45Z
dc.date.available2025-06-04T13:40:45Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractAIM: To examine the effects of amantadine, a drug with neuroprotective and anti-inflammatory activities on oxidative stress, tissue necrosis, apoptosis, and neurological recovery in an experimental rabbit spinal cord ischemia-reperfusion injury (SCIRI) model. MATERIAL and METHODS: A total of 32 rabbits were randomized into five groups: control, ischemia, vehicle, methylprednisolone (MP), and amantadine (AMT) (n=8/each). At 24th-hour neurological examination was performed, spinal cord tissues were collected, and biochemical and histopathological examinations were performed. RESULTS: When ischemia and vehicle groups were compared with control group, significant increase was seen in serum and tissue caspase-3, malondialdehyde (MDA), and myeloperoxidase (MPO) levels (p<0.001); significant decrease was seen in serum and tissue catalase (CAT) levels (p<0.001); and significant increase was seen in serum xanthine oxidase (XO) levels (p<0.001). When the ischemia group and the MP and AMT groups were compared, low serum and tissue caspase-3 levels (p<0.001), high serum and tissue CAT levels (p<0.001), significantly low serum XO levels (p<0.001), low serum and tissue MDA levels (p<0.05) and tissue MPO levels (p<0.001) were found. Both AMT and MP groups showed decreased histopathological score and higher number of normal neurons (p<0.001) compared to ischemia group. Both AMT and MP showed better modified Tarlov scores compared to the ischemia group (p<0.001). CONCLUSION: Our study found that AMT had antioxidant, anti-inflammatory, anti-apoptotic, and neuroprotective effects on SCIRI. We used biochemical, microscopic, and ultrastructural approaches to demonstrate these effects. AMT might be a candidate medication for SCIRI prophylaxis and treatment. © (2024), (Turkish Neurosurgical Society). All rights reserved.
dc.identifier.citationUnluer, C., Bektasoglu, P. K., Erguder, B. I., Arikok, A. T., Ermutlu, I., Gurer, B., & Kertmen, H. (2024). Amantadine’s Neuroprotective Effects in Rabbit Spinal Cord Ischemia/Reperfusion Model. Turkish Neurosurgery, 34(6).
dc.identifier.doi10.5137/1019-5149.JTN.45875-23.3
dc.identifier.endpage1144
dc.identifier.issn10195149
dc.identifier.issue6
dc.identifier.pmid39474964
dc.identifier.scopusqualityQ3
dc.identifier.startpage1133
dc.identifier.urihttp://dx.doi.org/10.5137/1019-5149.JTN.45875-23.3
dc.identifier.urihttps://hdl.handle.net/20.500.12713/7296
dc.identifier.volume34
dc.identifier.wosWOS:001366849800024
dc.identifier.wosqualityQ3
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorGürer, Bora
dc.institutionauthoridBora Gürer / 0000-0003-1500-6184
dc.language.isoen
dc.publisherTurkish Neurosurgical Society
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAmantadine
dc.subjectSpinal Cord Ischemia
dc.subjectReperfusion Injury
dc.subjectAntioxidant
dc.subjectAntiapoptotic
dc.titleAmantadine’s Neuroprotective Effects in Rabbit Spinal Cord Ischemia/Reperfusion Model
dc.typeArticle

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