Frequency of obesity and metabolic syndrome in childhood leukemia and lymphoma survivors

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dc.contributor.authorKartal, İbrahim
dc.contributor.authorAlaçam, Abdurrahman
dc.contributor.authorDağdemir, Ayhan
dc.contributor.authorDinçer, Oğuz Salih
dc.contributor.authorAlbayrak, Canan
dc.contributor.authorElli, Murat
dc.date.accessioned2022-01-28T08:19:07Z
dc.date.available2022-01-28T08:19:07Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: In this study, it was aimed to determine the prevalence and clinical features of obesity and metabolic syndrome, which are long-term effects of survivors after treatment in children with leukemia and lymphoma. Patients and methods: Patients with leukemia and lymphoma, who were diagnosed between 2000 and 2012 (at least 2 two years after remission) were included. Data obtained through reviewing the family history, demographic characteristics, anthropometric measurements, and laboratory parameters (blood glucose, lipid, and insulin levels) were analyzed and compared at the time of diagnosis, after the treatment and at time of the study. Results: Eighty nine patients (45 boys, 44 girls) were included (mean age: 14.7 ± 4.3 years): 77.5% had acute lymphoblastic leukemia, 11.2% had acute myeloid leukemia, and 11.2% had lymphoma. Overall, 46% patients had received radiotherapy, 7% had undergone surgery, and 2.2% had received stem cell transplantation in addition to chemotherapy. The mean duration of treatment was 2.4 years, and the time elapsed after treatment was 4.9 years. While only one had obesity at the diagnosis, a significant increase in obesity (20%), hypertension (15.7%), hyperglycemia (15%), insulin resistance (35%) were observed at the time of study, and family history of hypertension, dyslipidemia, and cardiovascular diseases were significantly higher in this subgroup. Conclusion: The prevalence of metabolic syndorme is higher in children with leukemia and lymphoma after treatment, and begins to increase with the initiation of treatment and continues to increase over time. These children should be followed-up for late-effects including metabolic syndrome through life-long period.en_US
dc.identifier.citationKartal İ, Alaçam A, Dağdemir A, Kara C, Dinçer OS, Albayrak C, Elli M. Frequency of obesity and metabolic syndrome in childhood leukemia and lymphoma survivors. Diabetol Metab Syndr. 2022 Jan 24;14(1):16.en_US
dc.identifier.doi10.1186/s13098-022-00790-4en_US
dc.identifier.issue1en_US
dc.identifier.pmid35073984en_US
dc.identifier.scopus2-s2.0-85123494808en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1186/s13098-022-00790-4
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2434
dc.identifier.volume14en_US
dc.identifier.wosWOS:000746594100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKara, Cengiz
dc.language.isotren_US
dc.relation.ispartofDiabetol Metab Syndren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCancer Survivoren_US
dc.subjectChildhood Leukemia-Lymphomaen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectObesityen_US
dc.titleFrequency of obesity and metabolic syndrome in childhood leukemia and lymphoma survivorsen_US
dc.typeArticleen_US

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