Mission impossible for cellular internalization: When porphyrin alliance with UiO-66-NH2 MOF gives the cell lines a ride

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100en_US
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorAhmadi, Sepideh
dc.contributor.authorJajarmi, Vahid
dc.contributor.authorAshrafizadeh, Milad
dc.contributor.authorZarrabi, Ali
dc.contributor.authorHaponiuk, Józef T.
dc.contributor.authorSaeb, Mohammad Reza
dc.contributor.authorLima, Eder C.
dc.contributor.authorRabiee, Mohammad
dc.contributor.authorRabiee, Navid
dc.date.accessioned2022-06-14T11:35:50Z
dc.date.available2022-06-14T11:35:50Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractIs it possible to accelerate cell internalization by hybridization of nanomaterials? Herein we support the realization of using metal-organic frameworks (MOFs) with the assistance of rigid porphyrin structure (H2TMP) aimed at drug loading, drug release, relative cell viability, and targeted in vitro drug delivery. There are several MOFs, i.e., UiO-66-NH2 (125 ± 12.5 nm), UiO-66-NH2 @H2TMP (160 ± 14 nm), UiO-66-NH2 @H2TMP@DOX, and UiO-66-NH2 @H2TMP@DOX@RO were synthesized and characterized applying HEK-293, HT-29, MCF-7, and MCF-10A cell lines. MTT investigations proved a significantly higher relative cell viability for H2TMP-aided leaf-extract-coated nanocarriers (above 62 % relative cell viability). Furthermore, the rigid H2TMP structure improved drug loading capacity by 24 % through an enhanced hydrogen bond, van der Waals, and ?-? interactions. The in vitro targeted drug delivery experiments were conducted on HT-29 and MCF-7 cell lines. First, nanocarriers were treated with HT-29 cells, where UiO-66-NH2 @H2TMP@DOX@RO appeared as the best nanocarrier. Then, the selected nanocarrier was extracted from the HT-29 cell line and treated with the MCF-7 cell line. For the first time, the DOX remained inside the UiO-66-NH2 @H2TMP@DOX@RO after successful delivery to the HT-29 cell lines was observed on the MCF-7 cell line, and the second targeted drug delivery was performed. The results of this survey can enlighten the future ahead of cell internalization in MOF-based hybrid nanostructures. © 2022 Elsevier B.V.en_US
dc.identifier.citationAhmadi, S., Jajarmi, V., Ashrafizadeh, M., Zarrabi, A., Haponiuk, J. T., Saeb, M. R., . . . Rabiee, N. (2022). Mission impossible for cellular internalization: When porphyrin alliance with UiO-66-NH2 MOF gives the cell lines a ride. Journal of Hazardous Materials, 436 doi:10.1016/j.jhazmat.2022.129259en_US
dc.identifier.doi10.1016/j.jhazmat.2022.129259en_US
dc.identifier.issn0304-3894en_US
dc.identifier.scopus2-s2.0-85131428555en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jhazmat.2022.129259
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2889
dc.identifier.volume436en_US
dc.identifier.wosWOS:000810939700003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Hazardous Materialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDoxorubicinen_US
dc.subjectGreen MOFen_US
dc.subjectHT-29en_US
dc.subjectTargeted Drug Deliveryen_US
dc.subjectUiO-66-NH2en_US
dc.titleMission impossible for cellular internalization: When porphyrin alliance with UiO-66-NH2 MOF gives the cell lines a rideen_US
dc.typeArticleen_US

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