Molecular landscape of LncRNAs in prostate cancer: A focus on pathways and therapeutic targets for intervention

Basit Öğe Kaydı
dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.contributor.authorMirzaei, Sepideh
dc.contributor.authorAbad Paskeh, Mahshid Deldar
dc.contributor.authorOkina, Elena
dc.contributor.authorGholami, Mohammad Hossein
dc.contributor.authorHushmandi, Kiavash
dc.contributor.authorHashemi, Mehrdad
dc.contributor.authorKalu , Azuma
dc.contributor.authorZarrabi, Ali
dc.contributor.authorNabav, Noushin
dc.contributor.authorRabiee, Navid
dc.contributor.authorSharifi, Esmaeel
dc.contributor.authorKarimi-Maleh, Hassan
dc.contributor.authorAshrafizadeh, Milad
dc.contributor.authorKumar, Alan Prem
dc.contributor.authorWang, Yuzhuo
dc.date.accessioned2022-07-06T14:12:45Z
dc.date.available2022-07-06T14:12:45Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractBackground: One of the most malignant tumors in men is prostate cancer that is still incurable due to its heterog? enous and progressive natures. Genetic and epigenetic changes play signifcant roles in its development. The RNA molecules with more than 200 nucleotides in length are known as lncRNAs and these epigenetic factors do not encode protein. They regulate gene expression at transcriptional, post-transcriptional and epigenetic levels. LncRNAs play vital biological functions in cells and in pathological events, hence their expression undergoes dysregulation. Aim of review: The role of epigenetic alterations in prostate cancer development are emphasized here. Therefore, lncRNAs were chosen for this purpose and their expression level and interaction with other signaling networks in prostate cancer progression were examined. Key scientifc concepts of review: The aberrant expression of lncRNAs in prostate cancer has been well-docu? mented and progression rate of tumor cells are regulated via afecting STAT3, NF-?B, Wnt, PI3K/Akt and PTEN, among other molecular pathways. Furthermore, lncRNAs regulate radio-resistance and chemo-resistance features of prostate tumor cells. Overexpression of tumor-promoting lncRNAs such as HOXD-AS1 and CCAT1 can result in drug resistance. Besides, lncRNAs can induce immune evasion of prostate cancer via upregulating PD-1. Pharmacological compounds such as quercetin and curcumin have been applied for targeting lncRNAs. Furthermore, siRNA tool can reduce expression of lncRNAs thereby suppressing prostate cancer progression. Prognosis and diagnosis of prostate tumor at clinical course can be evaluated by lncRNAs. The expression level of exosomal lncRNAs such as lncRNA-p21 can be investigated in serum of prostate cancer patients as a reliable biomarkeren_US
dc.identifier.citationMirzaei S, Paskeh MDA, Okina E, Gholami MH, Hushmandi K, Hashemi M, Kalu A, Zarrabi A, Nabavi N, Rabiee N, Sharifi E, Karimi-Maleh H, Ashrafizadeh M, Kumar AP, Wang Y. Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention. J Exp Clin Cancer Res. 2022 Jul 1;41(1):214. doi: 10.1186/s13046-022-02406-1. PMID: 35773731; PMCID: PMC9248128.en_US
dc.identifier.doi10.1186/s13046-022-02406-1en_US
dc.identifier.issn1756-9966en_US
dc.identifier.issue214en_US
dc.identifier.pmid35773731en_US
dc.identifier.scopus2-s2.0-85133120751en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://doi.org/10.1186/s13046-022-02406-1
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2989
dc.identifier.volume41en_US
dc.identifier.wosWOS:000819418200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherPMCen_US
dc.relation.ispartofJournal of Experimental and Clinical Cancer Resarch: CRen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProstate Canceren_US
dc.subjectLong Non-coding RNA (lncRNA)en_US
dc.subjectMicroRNAen_US
dc.subjectDrug Resistanceen_US
dc.subjectImmune Evasionen_US
dc.subjectExosomeen_US
dc.titleMolecular landscape of LncRNAs in prostate cancer: A focus on pathways and therapeutic targets for interventionen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Mirzaei2022_Article_MolecularLandscapeOfLncRNAsInP.pdf
Boyut:
2.3 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PubMed İndeksli Yayınlar Koleksiyonu
Biyomedikal Mühendisliği Bölümü Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu