Cytotoxic platinum(II) complexes derived from saccharinate and phosphine ligands: synthesis, structures, DNA cleavage, and oxidative stress-induced apoptosis

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.contributor.authorİçsel, Ceyda
dc.contributor.authorYılmaz, Veysel T.
dc.contributor.authorCevatemre, Buse
dc.contributor.authorAygün, Muhittin
dc.contributor.authorUlukaya, Engin
dc.date.accessioned2020-08-30T20:06:29Z
dc.date.available2020-08-30T20:06:29Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractA series of the structurally related platinum(II) saccharinate (sac) complexes with alkylphenylphosphines, namely cis-[Pt(sac)(2)(PPh2Me)(2)]center dot DMSO (1), cis-[Pt(sac)(2)(PPhMe2)(2)] (2), cis-[Pt(sac)(2)(PPh2Et)(2)] (3), and cis-[Pt(sac)(2)(PPhEt2)(2)]center dot 2DMSO (4), were synthesized and fully characterized; their structures were determined by X-ray crystallography. All the complexes were investigated for their anticancer potentials on three human cancer cells including A549 (lung), MCF-7 (breast), and HCT116 (colon) in addition to a noncancerous human bronchial epithelial cells (BEAS-2B). Specifically, 1 and 3 showed significant cytotoxic effects against MCF-7 and HCT116 cell lines in comparison to cisplatin, and were considered as the most potent ones in the series. The cytotoxic complexes were found to cleave DNA efficiently. In addition, the binding interactions of the complexes with DNA were confirmed by enzyme inhibition and molecular docking studies. Complexes 1 and 3 were capable of inducing apoptosis and arrested the cell cycle at the DNA synthesis (S) phase in MCF-7 cells. Furthermore, 1 and 3 caused the excessive generation of reactive oxygen species (ROS), leading to mitochondrial dysfunction and double-strand DNA breaks.en_US
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [215Z230]en_US
dc.description.sponsorshipThe financial support from TUBITAK (project no. 215Z230) is gratefully acknowledged. We thank Prof. Dr. Ismail Ozdemir for collecting the NMR data.en_US
dc.identifier.citationIcsel, C., Yilmaz, V. T., Cevatemre, B., Aygun, M., & Ulukaya, E. (2020). Cytotoxic platinum (II) complexes derived from saccharinate and phosphine ligands: synthesis, structures, DNA cleavage, and oxidative stress-induced apoptosis. JBIC Journal of Biological Inorganic Chemistry, 25(1), 75-87.en_US
dc.identifier.doi10.1007/s00775-019-01736-4en_US
dc.identifier.endpage87en_US
dc.identifier.issn0949-8257en_US
dc.identifier.issn1432-1327en_US
dc.identifier.issue1en_US
dc.identifier.pmid31655897en_US
dc.identifier.scopus2-s2.0-85076509725en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage75en_US
dc.identifier.urihttps://doi.org/10.1007/s00775-019-01736-4
dc.identifier.urihttps://hdl.handle.net/20.500.12713/534
dc.identifier.volume25en_US
dc.identifier.wosWOS:000492655800002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUlukaya, Enginen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Biological Inorganic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPlatinum(Ii)en_US
dc.subjectSaccharinateen_US
dc.subjectPhosphineen_US
dc.subjectDna Cleavageen_US
dc.subjectCytotoxicityen_US
dc.titleCytotoxic platinum(II) complexes derived from saccharinate and phosphine ligands: synthesis, structures, DNA cleavage, and oxidative stress-induced apoptosisen_US
dc.typeArticleen_US

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