Blunt trauma induced closed femoral bone fracture in a rat model: are vessels safe to use for microsurgery? further insight into the zone of injury concept

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dc.authorscopusidAslı Datlı / 55939696800
dc.authorwosidAslı Datlı / AGJ-8835-2022
dc.contributor.authorBaşaran, Karaca
dc.contributor.authorDatlı, Aslı
dc.contributor.authorSağır, Mehmet
dc.contributor.authorSar, Mehmet
dc.contributor.authorBilgi, Esra
dc.date.accessioned2025-04-18T07:12:13Z
dc.date.available2025-04-18T07:12:13Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractBackground The study aims to investigate the zone of injury for major vessels after high-velocity traumas, as it is unclear whether avoiding vascular structures is necessary during microvascular anastomosis or how long it takes for them to be used again. Methods This study uses Doppler ultrasonography and a rat model to evaluate the histopathological changes and flow velocity of major vessels in the zone of injury after high-velocity trauma with closed femoral bone fracture. Osteosynthesis was performed using an intramedullary wire. Samples were collected from day 3 and week 3. The unaffected contralateral side is used as control. Results Results from arterial and venous flow assessments showed no evidence of ischemia in the extremities. Both arteries and veins were patent in both intervals and on the control side. The evaluation of the vessels showed arterial injury with a slightly reduced arterial flow on day 3 and week 3. The venous flow was slightly reduced on day 3 but not on week 3. Statistically, arterial endothelial injury was higher on day 3 than on week 3 ( p = 0.006). Media inflammation was also higher on day 3 ( p = 0.06). Arterial endothelization distribution was higher in week 3 ( p = 0.006). No significant differences were found in arterial media irregularity, necrosis, platelet aggregation, bleeding, and wall rupture. Venous samples showed no significant differences in any parameter ( p < 0.05). Conclusion High-velocity trauma increases the risk of thrombosis in vessels. Intravascular repair can start on day 2 and continue till week 3 with significant endothelization. Although physiologic findings do not alter arterial or venous flow, histologic findings support vessel injuries leading to potential complications. Microsurgery should be considered out of the injury zone until adequate vessel healing is achieved.
dc.identifier.citationBasaran, K., Datli, A., Sagir, M., Sar, M., & Bilgi, E. (2024). Blunt Trauma Induced Closed Femoral Bone Fracture in a Rat Model: Are Vessels Safe to Use for Microsurgery? Further Insight into the Zone of Injury Concept. Journal of Reconstructive Microsurgery.
dc.identifier.doi10.1055/a-2332-0263
dc.identifier.issn0743-684X
dc.identifier.issn1098-8947
dc.identifier.pmid38782027
dc.identifier.scopus2-s2.0-85194950972
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1055/a-2332-0263
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6428
dc.identifier.wosWOS:001252989200002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorDatlı, Aslı
dc.institutionauthoridAslı Datlı / 0000-0001-7023-5794
dc.language.isoen
dc.publisherThieme medical publ
dc.relation.ispartofJournal of reconstructive microsurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectZone of Injury
dc.subjectClosed Fracture
dc.subjectEndothelial Dysfunction
dc.titleBlunt trauma induced closed femoral bone fracture in a rat model: are vessels safe to use for microsurgery? further insight into the zone of injury concept
dc.typeArticle

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