An Insight into the Polymeric Nanoparticles Applications in Diabetes Diagnosis and Treatment

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dc.authoridZarepour, Atefeh/0000-0002-0347-5840
dc.authorwosidZarepour, Atefeh/AAH-9225-2020
dc.contributor.authorDehghani, Parisa
dc.contributor.authorRad, Monireh Esmaeili
dc.contributor.authorZarepour, Atefeh
dc.contributor.authorSivakumar, Ponnurengam Malliappan
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2024-05-19T14:40:48Z
dc.date.available2024-05-19T14:40:48Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractDiabetes Mellitus (DM) is a type of chronic metabolic disease that has affected millions of people worldwide and is known with a defect in the amount of insulin secretion, insulin functions, or both. This deficiency leads to an increase in the amounts of glucose, which could be accompanied by long-term damages to other organs such as eyes, kidneys, heart, and nervous system. Thus, introducing an appropriate approach for diagnosis and treatment of different types of DM is the aim of several researches. By the emergence of nanotechnology and its application in medicine, new approaches were presented for these purposes. The object of this review article is to introduce different types of polymeric nanoparticles (PNPs), as one of the most important classes of nanoparticles, for diabetic management. To achieve this goal, at first, some of the conventional therapeutic and diagnostic methods of DM will be reviewed. Then, different types of PNPs, in two forms of natural and synthetic polymers with different properties, as a new method for DM treatment and diagnosis will be introduced. In the next section, the transport mechanisms of these types of nano-carriers across the epithelium, via paracellular and transcellular pathways will be explained. Finally, the clinical use of PNPs in the treatment and diagnosis of DM will be summarized. Based on the results of this literature review, PNPs could be considered one of the most promising methods for DM management.en_US
dc.identifier.doi10.2174/1389557521666211116123002
dc.identifier.endpage216en_US
dc.identifier.issn1389-5575
dc.identifier.issn1875-5607
dc.identifier.issue2en_US
dc.identifier.pmid34784864en_US
dc.identifier.scopus2-s2.0-85147221132en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage192en_US
dc.identifier.urihttps://doi.org10.2174/1389557521666211116123002
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5018
dc.identifier.volume23en_US
dc.identifier.wosWOS:000950445100007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofMini-Reviews In Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectPolymeric Nanoparticlesen_US
dc.subjectNano-Carrieren_US
dc.subjectInsulinen_US
dc.subjectSensoren_US
dc.subjectHemoglobin A(1)Cen_US
dc.titleAn Insight into the Polymeric Nanoparticles Applications in Diabetes Diagnosis and Treatmenten_US
dc.typeReview Articleen_US

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