AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation

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dc.authoridAli Zarrabi / 0000-0003-0391-1769
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorEntezari, M.
dc.contributor.authorHashemi, D.
dc.contributor.authorTaheriazam, A.
dc.contributor.authorZabolian, A.
dc.contributor.authorZabolian, A.
dc.contributor.authorFakhri, F.
dc.contributor.authorHashemi, M.
dc.contributor.authorHushmandi, K.
dc.contributor.authorAshrafizadeh, M.
dc.contributor.authorZarrabi, A.
dc.contributor.authorErtas, Y.N.
dc.contributor.authorMirzaei, S.
dc.date.accessioned2022-01-18T08:43:15Z
dc.date.available2022-01-18T08:43:15Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractDiabetes mellitus (DM) is considered as a main challenge in both developing and developed countries, as lifestyle has changed and its management seems to be vital. Type I and type II diabetes are the main kinds and they result in hyperglycemia in patients and related complications. The gene expression alteration can lead to development of DM and related complications. The AMP-activated protein kinase (AMPK) is an energy sensor with aberrant expression in various diseases including cancer, cardiovascular diseases and DM. The present review focuses on understanding AMPK role in DM. Inducing AMPK signaling promotes glucose in DM that is of importance for ameliorating hyperglycemia. Further investigation reveals the role of AMPK signaling in enhancing insulin sensitivity for treatment of diabetic patients. Furthermore, AMPK upregulation inhibits stress and cell death in ? cells that is of importance for preventing type I diabetes development. The clinical studies on diabetic patients have shown the role of AMPK signaling in improving diabetic complications such as brain disorders. Furthermore, AMPK can improve neuropathy, nephropathy, liver diseases and reproductive alterations occurring during DM. For exerting such protective impacts, AMPK signaling interacts with other molecular pathways such as PGC-1?, PI3K/Akt, NOX4 and NF-?B among others. Therefore, providing therapeutics based on AMPK targeting can be beneficial for amelioration of DM.en_US
dc.identifier.citationEntezari, M., Hashemi, D., Taheriazam, A., Zabolian, A., Mohammadi, S., Fakhri, F., . . . Samarghandian, S. (2022). AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation. Biomedicine and Pharmacotherapyen_US
dc.identifier.doi10.1016/j.biopha.2021.112563en_US
dc.identifier.issn0753-3322en_US
dc.identifier.pmid35062059en_US
dc.identifier.scopus2-s2.0-85121910204en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2021.112563
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2388
dc.identifier.volume146en_US
dc.identifier.wosWOS:000761679200002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBiomedicine and Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetic patientsen_US
dc.subjectInsulin resistanceen_US
dc.subjectGlucose metabolismen_US
dc.subjectDiabetic complicationen_US
dc.subjectClinical applicationen_US
dc.titleAMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigationen_US
dc.typeArticleen_US

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