Molecularly imprinted polymer nanoparticles for the recognition of ellagic acid

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dc.authoridHatice Gülen / 0000-0001-7586-3108en_US
dc.authoridPınar Çakır Hatır / 0000-0002-3806-7118en_US
dc.authorscopusidHatice Gülen / 6603211102
dc.authorscopusidPınar Çakır Hatır / 57203277694
dc.authorwosidHatice Gülen / AFW-5375-2022en_US
dc.authorwosidPınar Çakır Hatır / S-8707-2019en_US
dc.contributor.authorYücel, Necla
dc.contributor.authorGülen, Hatice
dc.contributor.authorHatır, Pınar Çakır
dc.date.accessioned2022-08-08T12:34:35Z
dc.date.available2022-08-08T12:34:35Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesien_US
dc.description.abstractEllagic acid (EA) is one of the bioactive polyphenolic flavonoids found in many fruits. Over the years, various extraction methods have been developed to isolate pure EA from plant samples. These methods, however, have some disadvantages, such as low specificity and selectivity, not easy incorporation into industrial processes, and low-purification efficiency. The present study proposes an approach based on the molecular imprinting technique. We describe the nanoscale production of EA imprinted polymers for the first time. We develop a straightforward, efficient, and environmentally friendly precipitation polymerization method to synthesize molecularly imprinted polymer nanoparticles (nanoMIPs). To increase the affinity of nanoMIPs, we explore molecular interactions between EA and functional monomers before polymerization. The nanoMIPs are successfully synthesized with an excellent yield of 94.5%. The maximum binding capacity is 66.6 and 45.6 mu mol/g for EA imprinted and nonimprinted polymers, respectively. Furthermore, in the presence of quercetin, an EA analog, and other compounds in the pomegranate peel extract solution, nanoMIPs selectively retain EA. NanoMIPs will be a valuable analytical tool for separation and sensing applications, especially dispersive solid-phase extraction.en_US
dc.identifier.citationYucel, N., Gulen, H., Hatir, P. C. (2022). Context Sensitive Links 1 of 1 Molecularly imprinted polymer nanoparticles for the recognition of ellagic acid. Journal of Applied Polymer Science.en_US
dc.identifier.doi10.1002/app.52952en_US
dc.identifier.issn0021-8995en_US
dc.identifier.scopus2-s2.0-85135125185en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/app.52952
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3073
dc.identifier.wosWOS:000833039400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorGülen, Hatice
dc.institutionauthorHatır, Pınar Çakır
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF APPLIED POLYMER SCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomimeticen_US
dc.subjectNanostructured Polymersen_US
dc.subjectSeparation Techniquesen_US
dc.titleMolecularly imprinted polymer nanoparticles for the recognition of ellagic aciden_US
dc.typeArticleen_US

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