Timing of initiation of calcineurin inhibitors in pediatric haploidentical transplantation with post-transplantation cyclophosphamide: Effects on survival, relapse, and cytokine release syndrome

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dc.authoridVedat Uygun / 0000-0003-3257-7798en_US
dc.authorscopusidVedat Uygun / 10043117000
dc.authorwosidVedat Uygun / AGH-4534-2022
dc.contributor.authorUygun, Vedat
dc.contributor.authorKarasu, Gülsüm
dc.contributor.authorYalçın, Koray
dc.contributor.authorÖztürkmen, Seda
dc.contributor.authorDaloğlu, Hayriye
dc.contributor.authorÇelen, Safiye Suna
dc.contributor.authorHazar, Volkan
dc.contributor.authorYeşilipek, Akif
dc.date.accessioned2022-07-25T13:42:08Z
dc.date.available2022-07-25T13:42:08Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractBackground: The use of unmanipulated haploidentical hematopoietic stem cell transplantations (haplo-HSCT) with post-transplant cyclophosphamide (PTCY) in children has emerged as an acceptable alternative to the patients without a matched donor. However, the timing of calcineurin inhibitors (CNIs) used in combination with PTCY is increasingly becoming a topic of controversy. Method: We evaluated 49 children with acute leukemia who underwent unmanipulated haplo-HSCT with PTCY according to the initiation day of CNIs (pre- or post-cyclophosphamide [CY]). Results: There were no significant differences in the overall survival analysis between the 2 groups. The cumulative incidence of relapse at 2 years was 21.2% in the pre-CY group and 38.9% in the post-CY group (p = 0.33). Cytokine release syndrome (CRS) was observed more frequently in the post-CY group (p = 0.04). The overall survival and event-free survival at 2 years in patients with and without CRS in the pre-CY group were 42.9% versus 87.5% (p = 0.04) and 38.1% versus 87.5% (p = 0.04), respectively. Conclusion: Our study shows that the argument for starting CNI administration after CY is tenuous, and the rationale for not starting CNIs before CY needs to be reconsidered.en_US
dc.identifier.citationUygun V, Karasu G, Yalçın K, Öztürkmen S, Daloğlu H, Çelen SS, Hazar V, Yeşilipek A. Timing of Initiation of Calcineurin Inhibitors in Pediatric Haploidentical Transplantation with Post-Transplantation Cyclophosphamide: Effects on Survival, Relapse, and Cytokine Release Syndrome. Acta Haematol. 2022;145(4):362-370. doi: 10.1159/000521211. Epub 2021 Nov 30. PMID: 34847551.en_US
dc.identifier.doi10.1159/000521211en_US
dc.identifier.endpage370en_US
dc.identifier.issn0001-5792en_US
dc.identifier.issue4en_US
dc.identifier.pmid34847551en_US
dc.identifier.scopus2-s2.0-85123510630en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage362en_US
dc.identifier.urihttp://doi.org/10.1159/000521211
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3044
dc.identifier.volume145en_US
dc.identifier.wosWOS:000906458600003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUygun, Vedat
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofActa Haematologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Leukemiaen_US
dc.subjectCalcineurin Inhibitorsen_US
dc.subjectChildrenen_US
dc.subjectCyclophosphamideen_US
dc.subjectCytokine Release Syndromeen_US
dc.subjectHaploidenticalen_US
dc.titleTiming of initiation of calcineurin inhibitors in pediatric haploidentical transplantation with post-transplantation cyclophosphamide: Effects on survival, relapse, and cytokine release syndromeen_US
dc.typeArticleen_US

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