Cerebrolysin Amelioration of Spinal Cord Ischemia/ Reperfusion Injury in Rabbit Model

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dc.contributor.authorTonge, Caghan
dc.contributor.authorBektasoglu, Pinar Kuru
dc.contributor.authorGulmez, Ahmet
dc.contributor.authorTurkoglu, M. Erhan
dc.contributor.authorArikok, Ata Turker
dc.contributor.authorErguder, Berrin Imge
dc.contributor.authorGurer, Bora
dc.date.accessioned2024-05-19T14:39:03Z
dc.date.available2024-05-19T14:39:03Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractAIM: To investigate the effects of cerebrolysin on inflammation, oxidative stress, apoptosis, and neurologic recovery in the setting of an experimental rabbit model of spinal cord ischemia/reperfusion injury (SCIRI).MATERIAL and METHODS: Rabbits were randomly divided into five groups: control, ischemia, vehicle, methylprednisolone (30 mg/kg), and cerebrolysin (5 ml/kg) group. The rabbits in the control group underwent only laparotomy; the other groups underwent spinal cord ischemia and reperfusion injury for 20 minutes. Neurologic examination after 24 hours was based on the Modified Tarlov scale. Myeloperoxidase activities, catalase and malondialdehyde levels, and caspase-3 concentrations were determined in serum and tissue samples. Serum xanthine oxidase levels were studied and histopathological and ultrastructural changes were examined. RESULTS: After SCIRI, serum and tissue myeloperoxidase activities, malondialdehyde levels, caspase-3 concentrations, and serum xanthine oxidase activities were increased (p<0.01-0.001). Catalase levels were significantly diminished (p<0.001). Cerebrolysin treatment correlated with reduced myeloperoxidase and xanthine oxidase activities, malondialdehyde levels and caspase-3 concentrations; and with increased catalase levels (p<0.001, for all). The cerebrolysin group showed improved histopathological, ultrastructural, and neurological outcomes.CONCLUSION: For the first time in the literature, the current study reports anti-inflammatory, antioxidant, antiapoptotic, and neuroprotective effects of cerebrolysin in a SCIRI rabbit model.en_US
dc.description.sponsorshipTurkish Neurosurgical Societyen_US
dc.description.sponsorshipWe would like to thank Prof. Mustafa Fevzi Sargon for his scientific contribution for investigating the histopathological specimens. Preparation for publication of this article is partly supported by Turkish Neurosurgical Society. The authors would like to thank Enago ( www.enago.com ) for the English language review.en_US
dc.identifier.doi10.5137/1019-5149.JTN.42362-22.6
dc.identifier.endpage1027en_US
dc.identifier.issn1019-5149
dc.identifier.issue6en_US
dc.identifier.pmid37309634en_US
dc.identifier.scopus2-s2.0-85175046411en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1017en_US
dc.identifier.urihttps://doi.org10.5137/1019-5149.JTN.42362-22.6
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4689
dc.identifier.volume33en_US
dc.identifier.wosWOS:001115397600027en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAnti-Inflammatoryen_US
dc.subjectAntiapoptoticen_US
dc.subjectAntioxidanten_US
dc.subjectCerebrolysinen_US
dc.subjectIschemia/Reperfusionen_US
dc.subjectNeuroprotectionen_US
dc.subjectRabbitsen_US
dc.titleCerebrolysin Amelioration of Spinal Cord Ischemia/ Reperfusion Injury in Rabbit Modelen_US
dc.typeArticleen_US

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