Fabrication of a dual-drug-loaded smart niosome-g-chitosan polymeric platform for lung cancer treatment
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
MDPI
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Changes in weather conditions and lifestyle lead to an annual increase in the amount of lung cancer, and therefore it is one of the three most common types of cancer, making it important to find an appropriate treatment method. This research aims to introduce a new smart nano-drug delivery system with antibacterial and anticancer capabilities that could be applied for the treatment of lung cancer. It is composed of a niosomal carrier containing curcumin as an anticancer drug and is coated with a chitosan polymeric shell, alongside Rose Bengal (RB) as a photosensitizer with an antibacterial feature. The characterization results confirmed the successful fabrication of lipid-polymeric carriers with a size of nearly 80 nm and encapsulation efficiency of about 97% and 98% for curcumin and RB, respectively. It had the Korsmeyer-Peppas release pattern model with pH and temperature responsivity so that nearly 60% and 35% of RB and curcumin were released at 37 degrees C and pH 5.5. Moreover, it showed nearly 50% toxicity against lung cancer cells over 72 h and antibacterial activity against Escherichia coli. Accordingly, this nanoformulation could be considered a candidate for the treatment of lung cancer; however, in vivo studies are needed for better confirmation.
Açıklama
Anahtar Kelimeler
Niosome, Rose Bengal, Dual Responsive Nanocarrier, Anticancer, Antibacterial
Kaynak
Polymers
WoS Q Değeri
Q1
Scopus Q Değeri
Cilt
15
Sayı
2
Künye
Zarepour, A., Egil, A. C., Cokol Cakmak, M., Esmaeili Rad, M., Cetin, Y., Aydinlik, S., ... & Zarrabi, A. (2023). Fabrication of a Dual-Drug-Loaded Smart Niosome-g-Chitosan Polymeric Platform for Lung Cancer Treatment. Polymers, 15(2), 298.
